{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:29:47Z","timestamp":1790288987431,"version":"4.1.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>Mesonephric-like adenocarcinoma (MLA) is a rare tumor that occurs in the uterine corpus and ovary. It shares the morphological and immunohistochemical features of cervical mesonephric adenocarcinoma. Recent reports have suggested that a majority of ovarian MLAs are associated with endometriosis. Herein, we report the novel tumor of a 54-year-old Japanese woman with a history of bilateral ovarian endometriotic cysts who presented with abdominal distension. Pelvic magnetic resonance imaging revealed a 14-cm left ovarian cystic tumor with an intra-cystic solid mass. Histological examination revealed proliferation of columnar or cuboidal tumor cells forming round tubules, irregular tubular glands, fused glands, papillary structures, and solid nests.<\/jats:p>\n                  <jats:p>\n                    Additionally, associated endometriosis was observed in the cyst wall. The tumor cells were diffusely positive for GATA-binding protein 3 (GATA3) and negative for estrogen receptor. The tumor cells also showed wild-type p53, with retained expression of AT-rich interactive domain-containing protein 1A (ARID1) and phosphatase and tensin homolog (PTEN). Molecular analysis revealed an identical\n                    <jats:italic toggle=\"yes\">KRAS<\/jats:italic>\n                    p.G12V mutation in the tumor and the endometriotic cyst. The present tumor elucidates the pathogenesis and molecular mechanisms of ovarian MLA and demonstrates that ovarian MLA is an endometriosis-associated neoplasm. Further investigation into the pathogenesis and molecular mechanisms of ovarian MLA may assist in identifying potential therapeutic targets for this rare condition.\n                  <\/jats:p>","DOI":"10.1177\/10668969251333437","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T10:52:11Z","timestamp":1744714331000},"page":"1778-1783","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Ovarian Mesonephric-Like Adenocarcinoma Arising from an Endometriotic Cyst with an Identical\n                    <i>KRAS<\/i>\n                    Mutation in Both Components: A Case Report"],"prefix":"10.1177","volume":"33","author":[{"given":"Chika","family":"Eto","sequence":"first","affiliation":[{"name":"Shizuoka Cancer Center Hospital"},{"name":"Shizuoka Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1987-5942","authenticated-orcid":false,"given":"Tsubasa","family":"Hiraki","sequence":"additional","affiliation":[{"name":"Shizuoka Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Kawata","sequence":"additional","affiliation":[{"name":"Shizuoka Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Shizuoka Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Hirashima","sequence":"additional","affiliation":[{"name":"Shizuoka Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12895"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13970"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31090378"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147624"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614814"},{"issue":"11","key":"e_1_3_3_7_2","first-page":"1825","article-title":"High-throughput screening method of KRAS mutations at codons 12 and 13 in formalin-fixed paraffin-embedded tissue specimens of metastatic colorectal cancer","volume":"38","author":"Fukushima Y","year":"2011","unstructured":"Fukushima Y, Yanaka S, Murakami K, et al. High-throughput screening method of KRAS mutations at codons 12 and 13 in formalin-fixed paraffin-embedded tissue specimens of metastatic colorectal cancer. Gan To Kagaku Ryoho. 2011;38(11):1825\u20131835.","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002039"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000863"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/10668969231213390"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00799-6"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001766"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-05306-9"},{"key":"e_1_3_3_14_2","first-page":"15","article-title":"The landmark series: the future of pancreatic cancer clinical trials","author":"Seo YD","year":"2025","unstructured":"Seo YD, Katz MHG, Snyder RA. The landmark series: the future of pancreatic cancer clinical trials. Ann Surg Oncol. 2025:15. doi: https:\/\/doi.org\/10.1245\/s10434-024-16840-2. Epub ahead of print","journal-title":"Ann Surg Oncol"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969251333437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969251333437","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969251333437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:17:40Z","timestamp":1787645860000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969251333437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/10668969251333437"],"URL":"https:\/\/doi.org\/10.1177\/10668969251333437","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969251333437\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969251333437\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969251333437\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969251333437\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969251333437\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969251333437\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969251333437\/v3\/decision1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,15]]}}}