{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:28:42Z","timestamp":1787646522399,"version":"build-2736575974"},"reference-count":12,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    We report a 31-year-old woman with a history of low-grade, undifferentiated spindle cell sarcoma of the hand diagnosed at 10 years of age and subsequently amputated. The patient remained under surveillance without recurrence for over 20 years before she presented with multiple new masses in the skin of the head and neck. Biopsies confirmed recurrent sarcoma. Imaging studies revealed metastases within the lungs and peri-pancreatic tissue. Molecular analysis of these lesions showed a\n                    <jats:italic toggle=\"yes\">TPM3::NTRK1<\/jats:italic>\n                    fusion, and the patient started treatment on larotrectinib, on which she now remains, relapse and recurrence-free at 40 months. In presenting this patient, we hope to draw attention to the potentially overlooked provisional category of\n                    <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                    -rearranged spindle cell neoplasms that has been added to the fifth edition of the World Health Organization (WHO) classifications of pediatric tumors and soft tissue and bone tumors. While these neoplasms constitute only an estimated 1% of pediatric soft tissue neoplasms, discovering\n                    <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                    abnormalities in these lesions opens an important line of targeted therapy options, i.e., NTRK inhibitors. We hope to also show the community the potential for\n                    <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                    -rearranged spindle cell neoplasms to present with late local recurrence and metastases.\n                  <\/jats:p>","DOI":"10.1177\/10668969251343223","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T02:59:49Z","timestamp":1749524389000},"page":"1709-1712","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Late Recurrence of Spindle Cell Sarcoma in Association with\n                    <i>TPM3::NTRK1<\/i>\n                    Fusion"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2307-0696","authenticated-orcid":false,"given":"Xenia","family":"Parisi","sequence":"first","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center Division of Pathology and Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4391-1811","authenticated-orcid":false,"given":"Anindita","family":"Ghosh","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center Division of Pathology and Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Lien","family":"Wang","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center Division of Pathology and Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1704-9284","authenticated-orcid":false,"given":"Nahir","family":"Cortes-Santiago","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Texas Children's Hospital, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center Division of Pathology and Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Pediatric tumors [Internet]","author":"WHO Classification of Tumours Editorial Board","year":"2022","unstructured":"WHO Classification of Tumours Editorial Board. Pediatric tumors [Internet], WHO Classification of Tumours series, 5th ed.; Vol. 7. International Agency for Research on Cancer; 2022 [cited 2024 Nov 19]. Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/44.","edition":"5"},{"key":"e_1_3_3_3_2","volume-title":"Soft tissue and bone tumours [Internet]","author":"WHO Classification of Tumours Editorial Board","year":"2020","unstructured":"WHO Classification of Tumours Editorial Board. Soft tissue and bone tumours [Internet], WHO Classification of Tumours series, 5th ed.; vol. 3. International Agency for Research on Cancer; 2020 [cited 2024 Nov 19]. Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/33.","edition":"5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22671"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001203"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000675"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001297"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714448"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-3597"},{"key":"e_1_3_3_10_2","unstructured":"Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) for Soft Tissue Sarcoma V.4.2024. \u00a9 National Comprehensive Cancer Network Inc. 2024. All rights reserved. Accessed [Nov 26 2024]. To view the most recent and complete version of the guideline go online to NCCN.org."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001982"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0507"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01508-w"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969251343223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969251343223","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969251343223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:17:48Z","timestamp":1787645868000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969251343223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,9]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/10668969251343223"],"URL":"https:\/\/doi.org\/10.1177\/10668969251343223","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,9]]}}}