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Gamma heavy chain disease often resembles lymphoplasmacytic lymphoma clinically and histopathologically. Its diagnosis requires the demonstration of monoclonal heavy chains in the serum or urine. We present the clinical and pathologic history of a 69-year-old woman who was incidentally identified with a monotypic B-cell population during routine flow cytometry for her untreated T-cell large granular lymphocytic leukemia. Further workup was consistent with a diagnosis of gamma heavy chain disease.<\/jats:p>","DOI":"10.1177\/10668969251353415","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T03:08:59Z","timestamp":1751598539000},"page":"169-173","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathologic Findings in T-Cell Large Granular Lymphocytic Leukemia-Associated Gamma Heavy Chain Disease"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9529-4564","authenticated-orcid":false,"given":"Giby V.","family":"George","sequence":"first","affiliation":[{"name":"University of Rochester Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle S.","family":"Wallace","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3702-1123","authenticated-orcid":false,"given":"Chauncey R.","family":"Syposs","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPIIL1Y5QXTIBP"},{"key":"e_1_3_2_4_2","first-page":"4832619","article-title":"Two cases of gamma-heavy chain disease and a review of the literature","volume":"2018","author":"Ramasamy I","year":"2018","unstructured":"Ramasamy I, Rudzki Z. Two cases of gamma-heavy chain disease and a review of the literature. Case Rep Hematol. 2018;2018:4832619. 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