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In this report, we describe the first documented undifferentiated carcinoma with INI1 deficiency that originated in the gallbladder. Histological examination revealed a tumor composed of sheets of dyscohesive cells exhibiting a rhabdoid morphology. Immunohistochemical analysis confirmed the diagnosis of carcinoma with complete loss of INI1 expression. The diagnosis of INI1-deficient undifferentiated carcinoma can be challenging, and correlation of clinical findings, in conjunction with comprehensive immunohistochemical and molecular investigations, is crucial to establish the correct diagnosis and exclude potential mimicking entities.<\/jats:p>","DOI":"10.1177\/10668969251361171","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T07:05:42Z","timestamp":1755587142000},"page":"242-248","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["INI1-Deficient Carcinoma of the Gallbladder"],"prefix":"10.1177","volume":"34","author":[{"given":"Rasheeda","family":"Mohamedali","sequence":"first","affiliation":[{"name":"Department of Onco-Pathology, Homi Bhabha Cancer Hospital and Research Centre (HBNI University), New Chandigarh, 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