{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:18:37Z","timestamp":1787649517242,"version":"build-2736575974"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    Renal tumors that develop in congenitally malformed kidneys often fall outside standard histologic classifications. We present an unusual renal neoplasm in a 19-year-old boy with a hypoplastic right kidney. Computed tomography revealed a 70-mm sized unilocular cyst containing a 25-mm sized mural nodule, and laparoscopic nephroureterectomy was performed. Histologic examination showed low-grade papillary structures with reverse polarity. Immunohistochemistry demonstrated cytoplasmic (but not membranous) CA9 positivity, and RNA sequencing identified a pathogenic\n                    <jats:italic toggle=\"yes\">von Hippel-Lindau (VHL)<\/jats:italic>\n                    splicing-site mutation (c.341-2A\u2009&gt;\u2009G). Despite the\n                    <jats:italic toggle=\"yes\">VHL<\/jats:italic>\n                    alteration, the tumor did not fulfill the morphologic and immunohistochemical criteria for clear cell renal cell carcinoma and was diagnosed as unclassified renal cell carcinoma. This report illustrates the diagnostic complexity of renal tumors arising in congenital renal anomalies and underscores the importance of integrating molecular, morphologic, and immunophenotypic data when standard criteria are inconclusive.\n                  <\/jats:p>","DOI":"10.1177\/10668969251363265","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T06:05:19Z","timestamp":1755497119000},"page":"444-449","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Unclassified Renal Cell Carcinoma with Reverse Polarity and Pathogenic\n                    <i>von Hippel-Lindau<\/i>\n                    Mutation in a Congenital Renal Malformation"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5788-2560","authenticated-orcid":false,"given":"Emiko","family":"Sugawara","sequence":"first","affiliation":[{"name":"Cancer Institute Hospital, Japanese Foundation for Cancer Research"},{"name":"Japanese Foundation for Cancer Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-3861","authenticated-orcid":false,"given":"Kentaro","family":"Inamura","sequence":"additional","affiliation":[{"name":"Cancer Institute Hospital, Japanese Foundation for Cancer Research"},{"name":"Japanese Foundation for Cancer Research"},{"name":"Jichi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Akiya","sequence":"additional","affiliation":[{"name":"Cancer Institute Hospital, Japanese Foundation for Cancer Research"},{"name":"Japanese Foundation for Cancer Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-2879","authenticated-orcid":false,"given":"Akito","family":"Dobashi","sequence":"additional","affiliation":[{"name":"Cancer Institute Hospital, Japanese Foundation for Cancer Research"},{"name":"Japanese Foundation for Cancer Research"},{"name":"Cancer Institute, Japanese Foundation for Cancer Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Oguchi","sequence":"additional","affiliation":[{"name":"Cancer Institute Hospital, Japanese Foundation for Cancer Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Yonese","sequence":"additional","affiliation":[{"name":"Cancer Institute Hospital, Japanese Foundation for Cancer Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Cancer Institute Hospital, Japanese Foundation for Cancer Research"},{"name":"Japanese Foundation for Cancer Research"},{"name":"Cancer Institute, Japanese Foundation for Cancer Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"WHO classification of tumours","author":"WHO classification of tumours: Urinary and male genital tumours","year":"2022","unstructured":"WHO classification of tumours: Urinary and male genital tumours. WHO classification of tumours. 5th ed. International Agency for Research on Cancer; 2022.","edition":"5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.075"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2021.01.003"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493574"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3844"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201202231"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009183"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181570343"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00779-w"},{"key":"e_1_3_3_11_2","first-page":"152498","article-title":"Papillary renal neoplasm with reverse polarity shows benign behavior: results from a 77-case clinicopathological and molecular study","author":"Lee YI","unstructured":"Lee YI, Park JM, Yoon SY, Song C, Cho YM. Papillary renal neoplasm with reverse polarity shows benign behavior: results from a 77-case clinicopathological and molecular study. Ann Diagn Pathol. 2025 May:152498. doi:https:\/\/doi.org\/10.1016\/j.anndiagpath.2025.152498","journal-title":"Ann Diagn Pathol"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0479-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006030277"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13643-4"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2288-5"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969251363265","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969251363265","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969251363265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:20:39Z","timestamp":1787646039000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969251363265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,17]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/10668969251363265"],"URL":"https:\/\/doi.org\/10.1177\/10668969251363265","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,17]]}}}