{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:41:54Z","timestamp":1792428114817,"version":"4.5.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    Rosai-Dorfman disease is an uncommon histiocytic neoplasm that is often self-limiting; however, rarely, it exhibits aggressive behavior and may undergo biological transformation to histiocytic sarcoma. Pathogenic genetic drivers of Rosai-Dorfman disease include recurrent genetic abnormalities in\n                    <jats:italic toggle=\"yes\">KRAS<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">NRAS<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">ARAF,<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">MAP2K1.<\/jats:italic>\n                    Mutation of\n                    <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                    is a well-known oncogenic driver in histiocytic neoplasms, including up to 50% of Langerhans cell histiocytosis lesions, Erdheim-Chester disease, and adult and juvenile xanthogranuloma. However,\n                    <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                    mutations have been documented in only 4 reported Rosai-Dorfman disease specimens, and none were rearrangements. Herein, we report the first instance of Rosai-Dorfman disease with\n                    <jats:italic toggle=\"yes\">OSBPL11<\/jats:italic>\n                    ::\n                    <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                    gene rearrangement, a unique gene fusion, and describe its clinicopathological features.\n                  <\/jats:p>","DOI":"10.1177\/10668969251363992","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T06:33:12Z","timestamp":1755671592000},"page":"456-460","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Rosai-Dorfman Disease With Novel\n                    <i>BRAF<\/i>\n                    Fusion Involving the Central Nervous System"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2319-0284","authenticated-orcid":false,"given":"Jessica","family":"Alvarez-Lesmes","sequence":"first","affiliation":[{"name":"the University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Cassidy","sequence":"additional","affiliation":[{"name":"the University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"issue":"6","key":"e_1_3_2_2_2","first-page":"1169","article-title":"Adenitis with lipid excess, in children or young adults, seen in the Antilles and in Mali. (4 cases)","volume":"58","author":"Destombes P","year":"1965","unstructured":"Destombes P. Adenitis with lipid excess, in children or young adults, seen in the Antilles and in Mali. (4 cases). Bull Soc Pathol Exot Filiales. 1965;58(6):1169-1175.","journal-title":"Bull Soc Pathol Exot Filiales"},{"issue":"1","key":"e_1_3_2_3_2","first-page":"63","article-title":"Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity","volume":"87","author":"Rosai J","year":"1969","unstructured":"Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. 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