{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:56:45Z","timestamp":1790193405042,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Programmed death-ligand 1 (PD-L1) is an immune checkpoint molecule with proven therapeutic and prognostic implications. However, its prognostic significance in skin neoplasms remains controversial. In this study, we aimed to evaluate the prognostic value of PD-L1 expression in skin neoplasms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Scopus, and Web of Science databases up to March 2025, to evaluate overall survival (OS) and disease-free survival (DFS) as outcome measures. Subgroup analyses were performed based on tumor type. Heterogeneity and publication bias were assessed using I\u00b2 statistics and funnel plots, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 24 studies were included. In the meta-analysis of OS on 12 studies, PD-L1 expression was not significantly associated with survival [HR\u2009=\u20090.89, 95% CI: 0.70-1.12]. However, subgroup analysis showed that PD-L1 expression was associated with improved OS in Merkel cell carcinoma [HR\u2009=\u20090.39, 95% CI: 0.18-0.83]. For DFS (8 studies), PD-L1 expression showed no significant overall association [random-effects HR\u2009=\u20090.86, 95% CI: 0.54-1.38], but it predicted better DFS in melanoma and cutaneous squamous cell carcinoma, and worse DFS in cutaneous angiosarcoma and sebaceous gland carcinoma. Additionally, in squamous cell carcinoma, PD-L1 expression was significantly associated with the risk of lymph node metastasis [OR = 5.33, 95% CI: 2.21-12.89].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prognostic significance of PD-L1 expression in skin neoplasms appears to be subtype-specific, correlating with improved survival in some cancers such as Merkel cell carcinoma, but with worse outcomes in others like cutaneous angiosarcoma and sebaceous gland carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10668969251367457","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T06:22:06Z","timestamp":1755843726000},"page":"289-297","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Prognostic Significance of Programmed Death-Ligand 1 (PD-L1) in Skin Neoplasms: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5714-967X","authenticated-orcid":false,"given":"Alireza","family":"Abdollahi","sequence":"first","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0230-0207","authenticated-orcid":false,"given":"Emad","family":"Mehrtash","sequence":"additional","affiliation":[{"name":"Qazvin University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1878-0569","authenticated-orcid":false,"given":"Bita","family":"Jafarzadeh","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-7580","authenticated-orcid":false,"given":"Vahid","family":"Mehrtash","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2015.07.006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.146.s61.2.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20073"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003416"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.35278"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2019.05.010"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000377698"},{"key":"e_1_3_3_12_2","first-page":"22","article-title":"Dermoscopy, confocal microscopy and other non-invasive tools for the diagnosis of non-melanoma skin cancers and other skin conditions","volume":"97","author":"Malvehy J","year":"2017","unstructured":"Malvehy J, Pellacani G. 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