{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:18:31Z","timestamp":1787649511331,"version":"build-2736575974"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"intramural research fund of the Department of Pathology, UTSW"},{"name":"Philip O\u2019Bryan Montgomery, Jr, MD, endowment fund"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gynandroblastoma is an exceptionally rare ovarian sex cord-stromal tumor containing both male and female components. Due to its rarity, molecular data are limited, and its clinical behavior remains incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 2 tumors of gynandroblastoma diagnosed at 2 teaching hospitals. Clinicopathological data, including patient demographics, tumor characteristics, and outcomes, were collected. Immunohistochemistry (IHC) and next-generation sequencing (NGS) were performed on both tumors to evaluate for the presence of\n                      <jats:italic toggle=\"yes\">FOXL2<\/jats:italic>\n                      (Forkhead Box L2) and\/or\n                      <jats:italic toggle=\"yes\">DICER1<\/jats:italic>\n                      (dicer 1, ribonuclease III) mutations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both tumors were FIGO stage IA . Microscopically, tumor #1 contained well-differentiated Sertoli cell tumor (SCT) and adult-type granulosa cell tumor (AGCT) components, while tumor #2 comprised moderately differentiated Sertoli-Leydig cell tumor (SLCT) and AGCT components. Immunophenotypically, both tumors were positive for the sex cord-stromal markers calretinin and inhibin. NGS revealed the absence of\n                      <jats:italic toggle=\"yes\">FOXL2<\/jats:italic>\n                      c.402C&gt;G (p.Cys134Trp) in both tumors.\n                      <jats:italic toggle=\"yes\">DICER1<\/jats:italic>\n                      mutations were absent in both tumors. Both patients remained disease-free during follow-up periods of 6 and 62 months, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Gynandroblastoma remains a distinct and rare entity with characteristic histopathological and molecular features. Our findings align with previous studies, emphasizing the rarity of\n                      <jats:italic toggle=\"yes\">FOXL2<\/jats:italic>\n                      mutation and the absence of\n                      <jats:italic toggle=\"yes\">DICER1<\/jats:italic>\n                      mutations in tumors with an AGCT component, regardless of the male sex cord component. Further studies are needed to better understand its molecular pathogenesis and long-term outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10668969251378672","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T17:24:01Z","timestamp":1759166641000},"page":"495-500","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ovarian Gynandroblastoma: A Rare Sex Cord-Stromal Tumor with Unique Morphological, Genetic, and Clinical Features\u2014A Series of Two Patients with Clinicopathological and Molecular Analysis, and a Review of the Literature"],"prefix":"10.1177","volume":"34","author":[{"given":"Elena","family":"Lucas","sequence":"first","affiliation":[{"name":"UT Southwestern Medical Center"},{"name":"Parkland Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Molberg","sequence":"additional","affiliation":[{"name":"UT Southwestern Medical Center"},{"name":"Parkland Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-476X","authenticated-orcid":false,"given":"Lesley","family":"Conrad","sequence":"additional","affiliation":[{"name":"UT Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Niu","sequence":"additional","affiliation":[{"name":"UT Southwestern Medical Center"},{"name":"Parkland Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6282-0237","authenticated-orcid":false,"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"UT Southwestern Medical Center"},{"name":"Parkland Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"issue":"4","key":"e_1_3_2_2_2","first-page":"633","article-title":"Gynandroblastoma of the ovary","volume":"19","author":"Mechler EA","year":"1943","unstructured":"Mechler EA, Black WC. 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