{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:18:41Z","timestamp":1787649521504,"version":"build-2736575974"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the relationship between cervical dysplasia and tissue levels of nicotinamide phosphoribosyltransferase (NAMPT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Patients who underwent colposcopic biopsy due to human papilloma virus positivity were classified as normal tissue and cervical intraepithelial neoplasia (CIN) 1, CIN 2-3. These were stained with NAMPT antibodies using streptavidin-biotin peroxidase method (Invitrogen, 85-9043, CA, USA). The staining intensity was scored as: 0, 1, 2, and 3 for no, mild, moderate, and intense staining, respectively. The percentage score was classified as: 1, 2, and 3 for 1% to 33%, 34% to 66%, and 67% to 100% positivity, respectively. The product score was calculated. Totally, 86 patients were included in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The NAMPT staining scores were significantly higher in the CIN 2-3 group compared to the group with CIN 1\/normal (90% vs 9%; respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.000). No intense NAMPT staining was observed in any of the specimens with CIN 1 or normal results. The percentage score of 2 to 3 was seen in 83% and 12% for patients with and without CIN 2-3, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.000). Using a cutoff value for product score of 2, the test demonstrated a sensitivity, a negative-predictive value, a specificity, and a positive-predictive value of 96%, 98%, 80%, and 71%, respectively. Although the product score was 2 and higher for 96% of CIN 2-3 specimens, 78% of those with CIN 1 or normal results had that below 2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The NAMPT staining differs significantly among groups and may be a useful marker for distinguishing CIN 2-3 from normal tissue and CIN 1. That has potential to improve the sensitivity\u2013specificity of diagnosing and treating cervical premalignant lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10668969251378727","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T17:24:48Z","timestamp":1759166688000},"page":"385-391","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nicotinamide Phosphoribosyltransferase (NAMPT) as a New Marker in Cervical Preinvasive Lesions"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3320-7457","authenticated-orcid":false,"given":"Eda","family":"Kayali","sequence":"first","affiliation":[{"name":"Ankara Bilkent City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-4196","authenticated-orcid":false,"given":"Gunsu Kimyon","family":"Comert","sequence":"additional","affiliation":[{"name":"Ankara Bilkent City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-0982","authenticated-orcid":false,"given":"H\u00fclya Tosun","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Saglik Bilimleri University Antalya Training and Research Hospital, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6706-6915","authenticated-orcid":false,"given":"Tayfun","family":"Toptas","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology, Saglik Bilimleri University Antalya Training and Research Hospital, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9330-6241","authenticated-orcid":false,"given":"Mehmet","family":"G\u00f6ksu","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology, Saglik Bilimleri University Antalya Training and Research Hospital, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology, Saglik Bilimleri University Antalya Training and Research Hospital, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysel","family":"Uysal","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology, Saglik Bilimleri University Antalya Training and Research Hospital, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1053-1115","authenticated-orcid":false,"given":"Yagmur","family":"Soykan","sequence":"additional","affiliation":[{"name":"Yukses Ihtisas Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3491-4682","authenticated-orcid":false,"given":"Isin","family":"Ureyen","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology, Saglik Bilimleri University Antalya Training and Research Hospital, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660.2021"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(94)01970-i"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.10.016"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.10.006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.12341"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.01.001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2465"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.02.022"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1079\/bjn20041213"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2011_02_124"},{"issue":"5","key":"e_1_3_2_12_2","first-page":"522","article-title":"Over-expression of nicotinamide phosphoribosyltransferase in ovarian cancers","volume":"3","author":"Shackelford RE","year":"2010","unstructured":"Shackelford RE, Bui MM, Coppola D, Hakam A. 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