{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:19:03Z","timestamp":1787649543072,"version":"build-2736575974"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    Secondary angiosarcoma of the breast is a rare and aggressive malignancy, with characteristic\n                    <jats:italic toggle=\"yes\">MYC<\/jats:italic>\n                    amplification. It typically arises in the field of prior radiation for breast cancer treatment, or rarely, in patients with a history of radical mastectomy with axillary lymph node dissection. Concurrent angiosarcoma and carcinoma in the same breast is exceedingly rare. In this report, we describe a rare occurrence of concurrent\n                    <jats:italic toggle=\"yes\">MYC<\/jats:italic>\n                    -amplified angiosarcoma in the breast skin and recurrent carcinoma in the breast parenchyma in a patient without any history of breast radiation or axillary lymph node dissection. In addition, both angiosarcoma and carcinoma were\n                    <jats:italic toggle=\"yes\">MYC<\/jats:italic>\n                    amplified, but with distinct\n                    <jats:italic toggle=\"yes\">MYC<\/jats:italic>\n                    amplification patterns. The angiosarcoma demonstrated a 5\u2032\n                    <jats:italic toggle=\"yes\">MYC<\/jats:italic>\n                    only amplification with a breakpoint between the 5\u2032 and 3\u2032\n                    <jats:italic toggle=\"yes\">MYC<\/jats:italic>\n                    probes, while the carcinoma harbored a large amplification on chromosome 8q24.21, encompassing both 5\u2032\n                    <jats:italic toggle=\"yes\">MYC<\/jats:italic>\n                    and 3\u2032\n                    <jats:italic toggle=\"yes\">MYC<\/jats:italic>\n                    . This case report highlights the occurrence of secondary angiosarcoma arising in a patient without a history of prior radiotherapy or an axillary dissection, as well as the rare concurrence of angiosarcoma and carcinoma in the same breast. More intriguingly, the distinct\n                    <jats:italic toggle=\"yes\">MYC<\/jats:italic>\n                    gene amplification patterns in the concurrent angiosarcoma and carcinoma reflect the complexity of the\n                    <jats:italic toggle=\"yes\">MYC<\/jats:italic>\n                    gene in the tumorigenesis of different types of malignancies and may explain the different levels of MYC protein expression on immunohistochemistry.\n                  <\/jats:p>","DOI":"10.1177\/10668969251381319","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:11:12Z","timestamp":1763140272000},"page":"709-717","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Concurrent\n                    <i>MYC<\/i>\n                    -Amplified Secondary Angiosarcoma and Recurrent Carcinoma in the Breast: A Rare Presentation With Unique Clinical Features and Distinct\n                    <i>MYC<\/i>\n                    Amplification Patterns"],"prefix":"10.1177","volume":"34","author":[{"given":"Kristin J.","family":"Rybski","sequence":"first","affiliation":[{"name":"University of Rochester Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Fan","sequence":"additional","affiliation":[{"name":"University of Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Weiss","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine and Dentistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa","family":"Huston","sequence":"additional","affiliation":[{"name":"University of Rochester Medical 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