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Hyalinizing clear cell carcinoma of the thymus is an exceptionally rare subtype and poses significant diagnostic challenges when predominantly composed of eosinophilic cells. Here, we present a case report of thymic hyalinizing clear cell carcinoma predominantly composed of eosinophilic cells, along with a comprehensive literature review analyzing its clinical, histopathological, immunohistochemical, and molecular characteristics.<\/jats:p>","DOI":"10.1177\/10668969251382663","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:50:23Z","timestamp":1760032223000},"page":"536-541","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyalinizing Clear Cell Carcinoma of the Thymus Predominantly Composed of Eosinophilic Cells: A Case Report and Literature Review"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7428-4382","authenticated-orcid":false,"given":"Ying","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Pathology, The Thirteenth People's Hospital of Chongqing, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chongqing Public Health Medical Center, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Fu","sequence":"additional","affiliation":[{"name":"Daping Hospital, Amy Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Luo","sequence":"additional","affiliation":[{"name":"Daping Hospital, Amy Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021201802"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-009-0481-6"},{"key":"e_1_3_2_4_2","first-page":"617810","article-title":"Diagnosis of thymic clear cell carcinoma by cytology","volume":"2013","author":"Lale SA","year":"2013","unstructured":"Lale SA, Tiscornia-Wasserman PG, Aziz M. 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Hyalinising clear cell carcinoma of the thymus with EWSR1 translocation: report of a case. 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