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Accurate differentiation from other pigmented tumors, such as melanoma, pigmented paraganglioma, and pigmented renal cell carcinoma is essential for proper diagnosis and treatment. A retrospective review of 2 departmental archives (2000-2023) identified 2 pigmented renal epithelioid AML specimens. Clinical presentations, histopathological features, immunohistochemical profiles, and molecular findings were analyzed. Both specimens exhibited melanin pigmentation, and 1 tumor demonstrated unique molecular alterations, including\n                    <jats:italic toggle=\"yes\">TSC2<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    mutations. This study underscores the importance of meticulous histopathological evaluation and molecular profiling in diagnosing and managing this extremely rare variant of epithelioid AML.\n                  <\/jats:p>","DOI":"10.1177\/10668969251382747","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T08:55:23Z","timestamp":1763974523000},"page":"735-744","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Pigmented Renal Epithelioid Angiomyolipoma: A Case Report and Literature Review"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4543-2697","authenticated-orcid":false,"given":"Quinn","family":"Rainer","sequence":"first","affiliation":[{"name":"Beth Israel Deaconess Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6872-3094","authenticated-orcid":false,"given":"Li","family":"Lei","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4499-5221","authenticated-orcid":false,"given":"Yue","family":"Sun","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2023.03.017"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.5858\/2009-0637-RSR.1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnci.2013.05.002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817ed7a6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03420.x"},{"issue":"4","key":"e_1_3_2_7_2","first-page":"92","article-title":"Pigmented epithelioid angiomyolipoma of the kidney","volume":"56","author":"Reddy R","year":"2015","unstructured":"Reddy R, Lewin JR, Shenoy V. 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