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Due to the morphological and immunophenotypic overlap of RCC with hemangioblastoma-like features and renal hemangioblastoma, this might be a potential pitfall or conundrum in histopathological diagnosis. To reinforce the knowledge of this rare tumor, we present an example of RCC with hemangioblastoma-like features with leiomyomatous stroma and renal vein invasion in a 59-year-old man and confirm the diagnosis by histopathological examination and immunohistochemistry. In addition, we discuss its clinicopathological features and molecular characteristics by reviewing the relevant literature.<\/jats:p>","DOI":"10.1177\/10668969251383560","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:12:51Z","timestamp":1763140371000},"page":"745-752","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Renal Cell Carcinoma With Hemangioblastoma-Like Features and Leiomyomatous Stroma: A Rare Case Report and A Potential Pathological Diagnostic Pitfall"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8715-6520","authenticated-orcid":false,"given":"Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology, Zhuhai People's Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhuhai People's Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixing","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhuhai People's Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhuhai People's Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhuhai People's Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-019-03213-z"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2015-202900"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.04.022"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.162898"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1066896919840435"},{"issue":"2","key":"e_1_3_2_7_2","first-page":"103","article-title":"Clinicopathological analysis of clear cell renal cell carcinoma with hemangioblastoma component","volume":"50","author":"Huang HJ","year":"2021","unstructured":"Huang HJ, Chen MJ, Li XO, Zhong DR. 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