{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:18:36Z","timestamp":1787649516112,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>Basal cell carcinoma (BCC) with matrical differentiation is an extremely rare subtype of basal cell carcinoma. We present an example of BCC with matrical differentiation and review the relevant literature. A 75-year-old man presented with a rapidly enlarging nodule on his forehead, with the clinical diagnosis of squamous cell carcinoma. Given atypical matrical proliferation on initial biopsy, there was concern for pilomatrix carcinoma. However, a repeat biopsy confirmed a diagnosis of BCC with matrical differentiation. Immunohistochemically, the BCC lobules expressed BCL2 and BER-EP4, while the areas of matrical differentiation showed nuclear \u03b2-catenin expression. The tumor cells were negative for keratin 7. BCC with matrical differentiation predominantly affects men, with a mean age of 70 years. Most tumors occur in the head and neck area, and lesions are often slow-growing or asymptomatic. Differential diagnosis includes pilomatrix carcinoma. Outcomes are generally favorable following surgical excision, although 2 instances of lymph node metastasis have been reported.<\/jats:p>","DOI":"10.1177\/10668969251384328","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T17:17:21Z","timestamp":1762795041000},"page":"555-558","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Basal Cell Carcinoma With Matrical Differentiation: A Case Report and Literature Review"],"prefix":"10.1177","volume":"34","author":[{"given":"Samantha","family":"Keow","sequence":"first","affiliation":[{"name":"McMaster University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2391-1010","authenticated-orcid":false,"given":"Joshua","family":"Del Papa","sequence":"additional","affiliation":[{"name":"Western University"},{"name":"Department of Pathology and Laboratory Medicine, London Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-5216","authenticated-orcid":false,"given":"Matthew","family":"Cecchini","sequence":"additional","affiliation":[{"name":"Western University"},{"name":"Department of Pathology and Laboratory Medicine, London Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4341-9613","authenticated-orcid":false,"given":"Anurag","family":"Sharma","sequence":"additional","affiliation":[{"name":"Western University"},{"name":"Department of Pathology and Laboratory Medicine, London Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00349.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198812000-00006"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199208000-00001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12313"},{"key":"e_1_3_2_6_2","unstructured":"Chisholm C. \u201cNovel CTNNB1 Gene Mutation Explains Similarity of \u03b2-Catenin Staining in Pilomatricomas and Basal Cell Carcinomas with Matrical Differentiation.\u201d Presented at the American Society of Dermatopathology 47th Annual Meeting Scott and White Memorial Hospital and Texas A&M Health Sciences Center Temple TX USA (2010)."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318156dceb"},{"issue":"10","key":"e_1_3_2_8_2","first-page":"282","article-title":"Pilomatricoma: an unusual dermatologic neoplasm.","volume":"71","author":"DeRosa D","year":"2012","unstructured":"DeRosa D, Lin-Hurtubise K. Pilomatricoma: an unusual dermatologic neoplasm. Hawai\u2019i J Med Public Health. 2012;71(10):282\u2013286.","journal-title":"Hawai\u2019i J Med Public Health"},{"issue":"2","key":"e_1_3_2_9_2","first-page":"159","article-title":"Basal cell carcinoma with matrical differentiation.","volume":"35","author":"Goldman-L\u00e9vy G","year":"2015","unstructured":"Goldman-L\u00e9vy G, Frouin E, Soubeyran I, et al. Basal cell carcinoma with matrical differentiation. 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