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We present a 64-year-old man with a soft tissue mass of the supraspinatus that was perceived as an epithelioid angiosarcoma due to the largely epithelioid morphology and characteristic immunohistochemical profile. However, given the patient's pertinent hematologic history and an additional array of immunohistochemical stains, the neoplasm was regarded as a myeloid sarcoma. Much like melanomas, lymphomas can present in a number of different forms and fashions. Namely, myeloid sarcomas\u2014a mass-forming neoplasm composed of myeloid blasts effacing the surrounding tissue architecture\u2014can masquerade as a carcinoma or sarcoma not only morphologically, but also immunohistochemically. We consider the pitfalls experienced with this entity and further elaborate on the genetics discovered within this particularly challenging lesion.<\/jats:p>","DOI":"10.1177\/10668969251384889","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T17:17:41Z","timestamp":1762795061000},"page":"431-436","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Myeloid Sarcoma Versus Epithelioid Angiosarcoma: A Case Report of a Potential Diagnostic Pitfall"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2785-7301","authenticated-orcid":false,"given":"Jack R.","family":"Parker","sequence":"first","affiliation":[{"name":"Baylor University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2305-3292","authenticated-orcid":false,"given":"Arthur","family":"Bredeweg","sequence":"additional","affiliation":[{"name":"Baylor University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-7177","authenticated-orcid":false,"given":"John","family":"Krause","sequence":"additional","affiliation":[{"name":"Baylor University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6427-9969","authenticated-orcid":false,"given":"Ali","family":"Alani","sequence":"additional","affiliation":[{"name":"Baylor University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406186"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmac074"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2306-9759.2015.08.01"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.270"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.05.010"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-579136"},{"key":"e_1_3_2_8_2","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2017","unstructured":"Swerdlow SH, Campo E, Harris NL, et al. 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