{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:18:57Z","timestamp":1787649537711,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    In pathology (surgical pathology\/cytopathology) specimens,\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    species can be challenging to differentiate from other fungi that produce hyaline septate hyphae by morphology alone. It has been suggested that fruiting bodies\u2014if present\u2014indicate\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    . The aim of this study was to determine whether the presence of fruiting bodies in pathology specimens is specific for\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    . Specimens containing fungal hyphae with fruiting bodies were identified and fungal culture and PCR results were reviewed to determine the identity of the fungi. To determine whether fruiting bodies can be formed in tissue by other fungi, non-\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    fungi were included for analysis if cultures or PCR confirmed a non-\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    fungus. Fruiting bodies were present in specimens from 13 patients (12 surgical pathology, 1 cytology). In 11\/13, the identity of the fungus was confirmed (10\n                    <jats:italic toggle=\"yes\">Aspergillus fumigatus<\/jats:italic>\n                    , 1\n                    <jats:italic toggle=\"yes\">Rhizopus<\/jats:italic>\n                    species). In 6\/13,\n                    <jats:italic toggle=\"yes\">A. fumigatus<\/jats:italic>\n                    was confirmed by microbiologic cultures. In 4\/13,\n                    <jats:italic toggle=\"yes\">A. fumigatus<\/jats:italic>\n                    was confirmed by PCR on formalin-fixed paraffin-embedded tissue. In 2\/13 specimens, cultures\/PCR were not performed. The one\n                    <jats:italic toggle=\"yes\">Rhizopus<\/jats:italic>\n                    sp. was confirmed by culture. In most (10\/13) specimens, fruiting bodies of\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    consisted of yellow vesicles containing a row of radiating phialides, occasional stalks\/conidiophores and detached yellow conidia (spores) in the background. In contrast, fruiting bodies of the\n                    <jats:italic toggle=\"yes\">Rhizopus<\/jats:italic>\n                    sp. were sporangia (large spore-containing sacs) lacking phialides. To evaluate fruiting bodies in non-\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    fungi, 18 specimens were identified with hyphal structures in tissue with available microbiologic culture or PCR results. No fruiting bodies were identified in the 18 non-\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    fungal infections (11\n                    <jats:italic toggle=\"yes\">Fusarium<\/jats:italic>\n                    , 6 Mucorales order genera, 1\n                    <jats:italic toggle=\"yes\">Acrophialophora<\/jats:italic>\n                    ). In pathology specimens, fruiting bodies with the morphologic features described in this study (conidiophores with yellow-brown vesicles, attached phialides, detached yellow conidia) are specific for\n                    <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                    and can be differentiated from\n                    <jats:italic toggle=\"yes\">Rhizopus<\/jats:italic>\n                    , whose fruiting bodies feature sporangia (large spore-containing sacs lacking phialides).\n                  <\/jats:p>","DOI":"10.1177\/10668969251391356","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T16:48:02Z","timestamp":1765558082000},"page":"656-668","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Significance of Fruiting Bodies in Pathology Specimens: A Series of 13 Patients"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1242-1163","authenticated-orcid":false,"given":"Jacob","family":"Rattin","sequence":"first","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisha","family":"Misra","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa C.","family":"Policarpio-Nicolas","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9660-2599","authenticated-orcid":false,"given":"Sanjay","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206291"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0276-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.5858\/134.5.667"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14037"},{"key":"e_1_3_2_6_2","first-page":"29","volume-title":"Pathology of Infectious Diseases. 1st ed. Foundations in Diagnostic Pathology","author":"Lee Love G","year":"2014","unstructured":"Lee Love G. Hyalohyphomycoses. In: Pathology of Infectious Diseases. 1st ed. Foundations in Diagnostic Pathology. Elsevier; 2014:29."},{"key":"e_1_3_2_7_2","first-page":"1157","volume-title":"Koneman\u2019s Color Atlas and Textbook of Diagnostic Microbiology. Fifth Edition","author":"Winn Jr W","year":"2006","unstructured":"Winn Jr W, Allen S, Janda W, et al. Mycology. In: Koneman\u2019s Color Atlas and Textbook of Diagnostic Microbiology. Fifth Edition. Lippincott Williams and Wilkins; 2006:1157\u20131158."},{"key":"e_1_3_2_8_2","volume-title":"StatPearls","author":"Fosses Vuong M","year":"2024","unstructured":"Fosses Vuong M, Hollingshead CM, Waymack JR. Aspergillosis. In: StatPearls. StatPearls Publishing; 2024. Accessed November 5, 2024. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482241\/"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1536(83)80210-1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.37.1046"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/69.2.188"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20267"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01748_1.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1066896911425486"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.120623"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2015.025"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijpm.ijpm_920_22"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0642"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.5858\/2000-124-0883-IOTASO"},{"key":"e_1_3_2_20_2","first-page":"124","volume-title":"Atlast of Fundamental Infectious Disease Histopathology. Vol 1","author":"Procop G","year":"2018","unstructured":"Procop G, Pritt B. Fungal infections. In: Atlast of Fundamental Infectious Disease Histopathology. Vol 1. First. College of American Pathologists; 2018:124."},{"key":"e_1_3_2_21_2","first-page":"465","volume-title":"Pathology of Infectious Disease. First. Foundations in Diagnostic Pathology","author":"Lee Love G","year":"2015","unstructured":"Lee Love G. Hyalohyphomycoses. In: Pathology of Infectious Disease. First. Foundations in Diagnostic Pathology. Elsevier; 2015:465."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.70014"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/109.1.45"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02999.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23658"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2022.11.004"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840080609"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23231"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969251391356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969251391356","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969251391356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:22:38Z","timestamp":1787646158000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969251391356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/10668969251391356"],"URL":"https:\/\/doi.org\/10.1177\/10668969251391356","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,12]]}}}