{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:17:54Z","timestamp":1787833074102,"version":"build-2784847793"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    Molecular classifications in gastric cancer are expensive and require experience. This study aimed to establish a molecular-like classification and to investigate the correlation of the classification with clinicopathological features and its prognostic significance.\n                    <jats:bold>Materials-Methods:<\/jats:bold>\n                    In 202 gastric cancer patients who underwent surgery between 2011 and 2019, the clinicopathological features of the tumors were re-evaluated, and the tumors were grouped by molecular-like classification using immunohistochemistry (MLH1, PMS2, MSH2, MSH6, p53, E-cadherin) and chromosomal in situ hybridization (EBER): EBV positive tumors (EBV+), tumors with microsatellite instability (MSI), genomically stable tumors (GS), chromosomal unstable tumors (CUN) and unclassifiable gastric tumors (G-NOS).\n                    <jats:bold>Results:<\/jats:bold>\n                    Twelve of the patients were in the EBV+, 22 in the MSI, 27 in the GS, 76 in the CUN and 65 in the G-NOS group. EBV\u2009+\u2009tumors were associated with high-grade tubular\/papillary morphology and GS tumors were associated with poorly cohesive\/mixed type, while tumors in the MSI group were associated with low-grade tubular\/papillary morphology (p\u2009&lt;\u2009.0001). Marked tumor budding was the least in MSI tumors and the most in GS tumors (p\u2009=\u2009.018). The longest survival time was in the patients of EBV\u2009+\u2009group, while the shortest survival time was in the patients of GS group (p\u2009=\u2009.029). Cox regression analysis indicated that age, lymphovascular invasion, positive surgical margins, low-grade tubular and papillary histological types, two groups within molecular- like classification (MSI and GS) were independent prognostic factors (p\u2009&lt;\u2009.05).\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Molecular-like classification holds promise as a low-cost, easy-to-implement classification that can be used predictively in prognosis. However, molecular-based studies with large series are still needed to determine whether it is a pretest or alternative of molecular classifications.\n                  <\/jats:p>","DOI":"10.1177\/10668969251397612","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T18:40:47Z","timestamp":1767724847000},"page":"858-865","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular-Like Classification in Gastric Adenocarcinomas: Correlation with Clinicopathological Features and Prognosis"],"prefix":"10.1177","volume":"34","author":[{"given":"Gamze","family":"Dal","sequence":"first","affiliation":[{"name":"University of Health Sciences, Konya Beyhekim Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7406-0610","authenticated-orcid":false,"given":"Asuman","family":"Argon","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Izmir Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Departments of Medical Oncology, Izmir City Hospital, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enver","family":"\u0130lhan","sequence":"additional","affiliation":[{"name":"University of Health Sciences, University of Health Sciences, Izmir Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.14740\/gr1187"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13480"},{"key":"e_1_3_2_4_2","unstructured":"WHO Classification of Tumors Digestive System 5th Edition Chapter 3: Tumors of the stomach. 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