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The lesion was excised, and gross examination revealed the characteristic leaf-like clefts typical of phyllodes tumors. Histopathological analysis demonstrated a biphasic morphology, composed of epithelial and stromal components. Immunohistochemical staining showed positivity for estrogen receptor, GATA3, and mammaglobin in the epithelial component, while the stromal component was positive for CD34. This rare tumor highlights that phyllodes tumors can occur in the anogenital region of men and emphasizes the importance of distinguishing them from other anal tumors. Long-term follow-up is recommended after resection.<\/jats:p>","DOI":"10.1177\/10668969251397646","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T16:14:02Z","timestamp":1765815242000},"page":"945-949","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Anal Phyllodes Tumor in a Man: An Exceptionally Rare Case Report and Literature Review"],"prefix":"10.1177","volume":"34","author":[{"given":"Hui-Wen","family":"Chang","sequence":"first","affiliation":[{"name":"China Medical University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-An","family":"Chen","sequence":"additional","affiliation":[{"name":"China Medical University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"China Medical University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Shan","family":"Lin","sequence":"additional","affiliation":[{"name":"China Medical University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wang","sequence":"additional","affiliation":[{"name":"China Medical University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2020-2652","authenticated-orcid":false,"given":"Che-Chi","family":"Liao","sequence":"additional","affiliation":[{"name":"China Medical University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Breast Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2019","unstructured":"WHO Classification of Tumours Editorial Board. 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