{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:17:55Z","timestamp":1787833075123,"version":"build-2784847793"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>Only 43 patients with laryngeal melanosis have been reported to date. Concomitant malignancy and dysplasia of the upper aerodigestive tract, ranging from 26% to 50%, have been encountered with this condition. Given the above, we undertook this study to assess the burden of laryngeal melanosis diagnosed in a tertiary care center. This was a retrospective observational study done with a review of all patients with laryngeal biopsies received over the previous 5-year period (2017-2022), on encountering an index patient. A representative slide from each patient was stained with Masson Fontana and bleached with potassium permanganate, and immunohistochemistry was performed using S100 and HMB45 (PMEL), wherever feasible. Sixty-five patients with laryngeal biopsies reported were included in the study, and laryngeal melanosis was detected in 9 patients (14% prevalence) of the total laryngeal biopsies. Seven out of 9 patients were associated with neoplasm, 6 patients (67%) with concomitant squamous cell carcinoma, and 1 (11%) with moderate dysplasia. We add another 9 patients to the list of laryngeal melanosis, based on our extensive literature search, taking the total to 52. We observed instances where laryngeal melanosis co-occurred with malignancies of the upper aerodigestive tract. Identifying laryngeal melanosis during direct laryngoscopy can serve as a marker that encourages surgeons and pathologists to exercise prudence and ensure thorough investigation.<\/jats:p>","DOI":"10.1177\/10668969251398853","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T17:55:32Z","timestamp":1766080532000},"page":"873-878","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Untold Tales of Laryngeal Melanosis"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7982-4469","authenticated-orcid":false,"given":"Deepsheikha","family":"Dhand","sequence":"first","affiliation":[{"name":"Maharishi Markandeshwar Deemed to be University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-6998","authenticated-orcid":false,"given":"Neha","family":"Singh","sequence":"additional","affiliation":[{"name":"Maharishi Markandeshwar Deemed to be University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6445-9385","authenticated-orcid":false,"given":"Vishesh","family":"Dhawan","sequence":"additional","affiliation":[{"name":"Maharishi Markandeshwar Deemed to be University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1414-5799","authenticated-orcid":false,"given":"Ayushi","family":"Kediya","sequence":"additional","affiliation":[{"name":"Maharishi Markandeshwar Deemed to be University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6204-6969","authenticated-orcid":false,"given":"Vijay Shrawan","family":"Nijhawan","sequence":"additional","affiliation":[{"name":"Maharishi Markandeshwar Deemed to be University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197205000-00009"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900810"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2006.00260.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770058-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.18332\/tid\/82926"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.106567"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813497921"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/14622200600790039"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0581-4"},{"issue":"5","key":"e_1_3_2_11_2","first-page":"331","article-title":"A further patient of malignant melanoma of the larynx","volume":"92","author":"Baron F","year":"1971","unstructured":"Baron F, Legent F, Mussini, Neel L, Bruneau Y, Seite P. A further patient of malignant melanoma of the larynx. Rev Laryngol Otol Rhinol (Bord). 1971;92(5):331-337.","journal-title":"Rev Laryngol Otol Rhinol (Bord)"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1976.00780060089012"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309132891"},{"issue":"1","key":"e_1_3_2_14_2","first-page":"10","article-title":"Melanosis of the larynx: a patient report","volume":"1","author":"Di Gregorio C","year":"1983","unstructured":"Di Gregorio C, De Gaetani CF. Melanosis of the larynx: a patient report. 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