{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:17:53Z","timestamp":1787833073808,"version":"build-2784847793"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"\n \n \n Gastrointestinal stromal tumor accounts for approximately 80% of mesenchymal tumors and 1% to 3% of all gastrointestinal system malignancies.\n KIT<\/jats:italic>\n or\n PDGFRA<\/jats:italic>\n mutations are identified in approximately 92-93% of gastrointestinal stromal tumors. Both\n KIT<\/jats:italic>\n and\n PDGFRA<\/jats:italic>\n mutations are associated with tyrosine kinase receptor signaling pathways and are considered mutually exclusive. Herein, we report a patient with sporadic multiple gastrointestinal stromal tumors harboring mutually exclusive\n KIT<\/jats:italic>\n and\n PDGFRA<\/jats:italic>\n mutations in separate tumors and review similar patients in the literature.\n <\/jats:p>\n <\/jats:sec>\n \n Patient Presentation<\/jats:title>\n \n A 60-year-old male patient presented with abdominal pain. Abdominal computed tomography revealed two distinct lesions in the stomach. The patient underwent distal gastrectomy, and pathological examination demonstrated that both lesions were gastrointestinal stromal tumors. Interestingly, the tumors exhibited different morphologies (epithelioid and spindle cell), distinct immunohistochemical profiles, and harbored different mutations (\n KIT<\/jats:italic>\n and\n PDGFRA<\/jats:italic>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Sporadic multiple gastrointestinal stromal tumors may have different morphological and immunohistochemical features, and they may also harbor two mutually exclusive mutations, such as\n KIT<\/jats:italic>\n and\n PDGFRA<\/jats:italic>\n . Recognition of this possibility is crucial for accurate diagnosis and the development of personalized therapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10668969251404486","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T15:26:49Z","timestamp":1766503609000},"page":"990-996","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sporadic Multiple Gastrointestinal Stromal Tumors With Distinct KIT and PDGFRA Mutations in Two Separate Tumors: A Case Report and Literature Review"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1973-1279","authenticated-orcid":false,"given":"Egemen","family":"Akincioglu","sequence":"first","affiliation":[{"name":"University of Health Science, Gulhane Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7471-1330","authenticated-orcid":false,"given":"Elif Yagmur","family":"Ciftci","sequence":"additional","affiliation":[{"name":"University of Health Science, Gulhane Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1637-7553","authenticated-orcid":false,"given":"Hale","family":"Kivrak","sequence":"additional","affiliation":[{"name":"University of Health Science, Gulhane Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugur","family":"Bozlar","sequence":"additional","affiliation":[{"name":"University of Health Science, Gulhane Education and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2917-6646","authenticated-orcid":false,"given":"Onder","family":"Bozdogan","sequence":"additional","affiliation":[{"name":"University of Health Science, Gulhane Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.28828"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15051498"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15072074"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.577"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1789204"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000158"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-024-01024-8"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000463"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050679"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2010.42.3.135"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.152708"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-02454-x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-020-00939-7"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S197560"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2014.01.019"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3180cac5f7"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.28209"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000146010.92933.de"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969251404486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969251404486","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969251404486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:22:46Z","timestamp":1787829766000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969251404486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/10668969251404486"],"URL":"https:\/\/doi.org\/10.1177\/10668969251404486","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,23]]}}}