{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:27:23Z","timestamp":1787740043239,"version":"build-2784847793"},"reference-count":67,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">PALB2<\/jats:italic>\n                    plays a crucial role in DNA repair by interacting with\n                    <jats:italic toggle=\"yes\">BRCA1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">BRCA2<\/jats:italic>\n                    . To clarify the clinicopathological impact of somatic PALB2 variants, we analyzed tumor DNA extracted from formalin-fixed, paraffin-embedded (FFPE) breast cancer specimens from 81 patients. Targeted next-generation sequencing identified 1\u202f514 variants, including 84 pathogenic or likely pathogenic variants and 9 genes with high mutation frequency; 2 deleterious somatic\n                    <jats:italic toggle=\"yes\">PALB2<\/jats:italic>\n                    variants were detected in 33% of samples. To explore transcriptional effects, we analyzed publicly available METABRIC mRNA expression data and found that elevated\n                    <jats:italic toggle=\"yes\">PALB2<\/jats:italic>\n                    mRNA levels were significantly associated with ER-\/PR- tumors and poorer survival outcomes. High\n                    <jats:italic toggle=\"yes\">PALB2<\/jats:italic>\n                    expression remained an independent predictor of shorter overall survival and relapse-free survival. These findings highlight the clinical importance of somatic\n                    <jats:italic toggle=\"yes\">PALB2<\/jats:italic>\n                    mutations and the prognostic value of\n                    <jats:italic toggle=\"yes\">PALB2<\/jats:italic>\n                    expression in breast cancer.\n                  <\/jats:p>","DOI":"10.1177\/10668969251414861","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:05:36Z","timestamp":1773407136000},"page":"1123-1133","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prediction of Specific Survival and Clinicopathological Impact of Somatic PALB2 Mutations and Pathogenic\/Likely Pathogenic Variants (PV\/LPV) in Breast Cancer: A Cohort Study of 81 Patients"],"prefix":"10.1177","volume":"34","author":[{"given":"Yousef M.","family":"Hawsawi","sequence":"first","affiliation":[{"name":"Research Center, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi Arabia"},{"name":"Department of Biochemistry &amp; 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