{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:55:45Z","timestamp":1789584945620,"version":"build-2803163510"},"reference-count":42,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    Multiple endocrine neoplasia (MEN) syndromes are a group of rare autosomal dominant hereditary disorders that are classified into 5 distinct types. MEN2A, the most common type of MEN2, is associated with mutations and variants of\n                    <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                    , which are continually being updated. However, studies regarding\n                    <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                    mutations\/variants related to MEN2A in the Chinese population are scarce, and patients involving MEN2A along with other differentiated thyroid tumors are rarer. We report a 54-year-old Chinese woman diagnosed with MEN2A and multiple follicular-derived thyroid tumors. Ultrasonography and computed tomography revealed a nodule in the thyroid and a nodule in the left adrenal gland. Laboratory investigations revealed elevated levels of both calcitonin and parathyroid hormone. The patient also had an 8-year history of hypertension, which normalized following the adrenal mass resection. Pathology identified 3 types of thyroid tumors and one type of adrenal tumor: the thyroid tumors consisted of medullary thyroid carcinoma, follicular adenoma, and papillary thyroid carcinoma, while the adrenal tumor was pheochromocytoma. Whole exome sequencing identified multiple germline mutations in the\n                    <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                    proto-oncogene, specifically R114H, A432A, and G691S. This report suggests that\n                    <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                    variants in MEN2A patients from the Chinese population may differ from the common\n                    <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                    variants. Additionally, MEN2A patients may present with thyroid follicular epithelial-derived tumors; however, further studies are necessary to determine any potential associations with\n                    <jats:italic toggle=\"yes\">RET<\/jats:italic>\n                    variants.\n                  <\/jats:p>","DOI":"10.1177\/10668969251415524","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T08:37:56Z","timestamp":1771403876000},"page":"1295-1302","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Rare\n                    <i>RET<\/i>\n                    Variants in a Patient With MEN2A and Multiple Follicular-Derived Thyroid Tumors: A Case Report and Review of the Literature"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3331-433X","authenticated-orcid":false,"given":"Yankun","family":"Song","sequence":"first","affiliation":[{"name":"Sichuan University West China Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Sichuan University West China Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2688-0432","authenticated-orcid":false,"given":"Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"Sichuan University West China Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14394"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-022-09705-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.03.035"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0335"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/03000605221110698"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0919"},{"issue":"10","key":"e_1_3_3_8_2","first-page":"1479","article-title":"Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901\u20132014: a nationwide study","volume":"2018","author":"Mathiesen JS","unstructured":"Mathiesen JS, Kroustrup JP, Vestergaard P, et al. Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901\u20132014: a nationwide study. Clin Epidemiol. 2018(10):1479\u20131487.","journal-title":"Clin Epidemiol"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0277"},{"issue":"12","key":"e_1_3_3_10_2","first-page":"1519","article-title":"Human ret proto-oncogene mapped to chromosome 10q11.2","volume":"4","author":"Ishizaka Y","year":"1989","unstructured":"Ishizaka Y, Itoh F, Tahira T, et al. Human ret proto-oncogene mapped to chromosome 10q11.2. 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