{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:26:18Z","timestamp":1787739978175,"version":"build-2784847793"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>Villous adenoma (VA) of the renal pelvis is a rare intestinal epithelial neoplasm. It generally arises in elderly men and is frequently associated with chronic irritation, infection, or long-standing obstruction, most often due to nephrolithiasis or hydronephrosis. We report four previously unpublished patients diagnosed with VA of the renal pelvis. Each patient was evaluated clinicopathologically, radiologically, immunohistochemically to clarify morphologic diversity and biological behavior. We also review previously reported patients in the literature. All four patients were men, aged 45\u201370 years, each with common history of chronic infection or calculi. Radiological findings revealed advanced hydronephrosis and mucin-filled collecting systems (muconephrosis). Grossly, the lesions were mucinous and cystically dilated. Microscopically, the lesions from Patient 1 and 2 showed classic villiform mucinous epithelium without invasion; the lesion from Patient 3 exhibited serrated adenoma-like architecture with dysplastic nuclei; the lesion from Patient 4 demonstrated low-grade dysplasia with preserved crypt morphology. Immunohistochemically, all lesions expressed intestinal markers including KRT20, CDX2, SATB2, with variable KRT7 expression, wild-type p53 (TP53) expression. None of the lesions showed invasive growth or recurrence during follow-up. VA of the renal pelvis represents an intestinal-type lesion of upper urinary tract that develops in setting of chronic irritation and mucus accumulation and may be associated with intestinal metaplasia. Because its clinical and radiologic features often mimic inflammatory or cystic disease, histopathologic evaluation is essential for accurate diagnosis. Recognition of this rare entity is crucial to differentiate it from mucinous adenocarcinoma, as complete surgical excision is curative and long-term prognosis is excellent.<\/jats:p>","DOI":"10.1177\/10668969261422253","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:26:43Z","timestamp":1774276003000},"page":"1180-1188","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Villous Adenoma of the Renal Pelvis: Clinicopathologic Spectrum and Diagnostic Considerations"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0537-3127","authenticated-orcid":false,"given":"Busra","family":"Yaprak Bayrak","sequence":"first","affiliation":[{"name":"School of Medicine"},{"name":"Kocaeli University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"Oznur","sequence":"additional","affiliation":[{"name":"School of Medicine, Nam\u0131k Kemal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suheda Zeynep","family":"Seday","sequence":"additional","affiliation":[{"name":"School of Medicine"},{"name":"Kocaeli University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"School of Medicine"},{"name":"Kocaeli University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve Meryem","family":"Kiran","sequence":"additional","affiliation":[{"name":"Ankara Bilkent State Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleyman","family":"Alt\u0131ntas","sequence":"additional","affiliation":[{"name":"Adana City Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8204-4666","authenticated-orcid":false,"given":"Nil","family":"Akcal\u0131","sequence":"additional","affiliation":[{"name":"Adana City Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0929-0940","authenticated-orcid":false,"given":"Mahmut","family":"Akgul","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital"},{"name":"Atlas University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.144653"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2021.283"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2019.100911"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i26.6159"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.8397"},{"key":"e_1_3_2_7_2","first-page":"102325","article-title":"Intestinal-type adenocarcinoma arising from a villous adenoma in the renal pelvis in the context of a kidney abscess","volume":"46","author":"Rochio-Tafoya A","year":"2023","unstructured":"Rochio-Tafoya A, Garc\u00eda-Mu\u00f1iz JA, Flores-Guti\u00e9rrez JP, Guti\u00e9rrez-Gonz\u00e1lez A, Barboza-Quintana O, Garza-Guajardo R. Intestinal-type adenocarcinoma arising from a villous adenoma in the renal pelvis in the context of a kidney abscess. Case Report. Urol Case Rep. 2023;46:102325.","journal-title":"Case Report. Urol Case Rep"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01707-7"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-1591.74478"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.12.051"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2012.03144.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.257"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1066896913502225"},{"issue":"7","key":"e_1_3_2_14_2","first-page":"438","article-title":"Villous adenoma of the urinary tract: a clinicopathological study","volume":"42","author":"Yin W","year":"2013","unstructured":"Yin W, Mo XL, Wen ZH, Zhou XZ, Zhou MY, Wei HM. Villous adenoma of the urinary tract: a clinicopathological study. Zhonghua Bing Li Xue Za Zhi. 2013;42(7):438\u2013441.","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000188617.65532.1d"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00120-006-1159-7"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261422253","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969261422253","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261422253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:14:15Z","timestamp":1787739255000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969261422253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/10668969261422253"],"URL":"https:\/\/doi.org\/10.1177\/10668969261422253","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]}}}