{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:27:23Z","timestamp":1787740043183,"version":"build-2784847793"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Phyllodes tumors (PT) are fibroepithelial breast lesions with variable clinical behavior and histological features that frequently overlap with those of fibroadenomas. Accurate differentiation is critical, as PT may exhibit aggressive behavior. However, their distinction is particularly challenging in core needle biopsy, especially for benign and borderline PT, due to the limited amount of tissue provided by this technique. This meta-analysis investigates histological features that improve the distinction between fibroadenomas and PT in core needle biopsies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched databases for studies comparing the core needle biopsy histologic features of lesions diagnosed as fibroadenoma or PT in the follow-up histopathological evaluation of the surgical specimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 14 studies, comprising 1413 patients. The PT group exhibited significantly higher rates of infiltrative margins (OR 6.06; 95% CI 2.13-17.22;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01), peri-epithelial stromal accentuation (OR 3.66; 95% CI 1.62-8.24;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01), stromal fragmentation (OR 6.93; 95% CI 2.66-18.04;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01), stromal overgrowth (OR 5.06; 95% CI 2.46-10.38;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01), cellular atypia (OR 9.04; 95% CI 5.15-15.89;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01), mitotic activity (OR 11.88; 95% CI 5.26-28.87;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01), and stromal hypercellularity (OR 9.67; 95% CI 5.58-16.78;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01). However, no statistically significant differences were found between the groups regarding the presence of adipose tissue within the lesion (OR 2.69; 95% CI 0.78-9.23;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.12) or the presence of intracanalicular pattern (OR 1.02; 95% CI 0.55-1.92;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.94). PTs were more frequent among older patients (MD 2.88; 95% CI 0.85-4.91;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01) and were larger (MD 1.07; 95% CI 0.79-1.35;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10668969261422683","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T15:28:16Z","timestamp":1776180496000},"page":"1089-1097","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Histological Features of Phyllodes Tumor and Fibroadenoma in Breast Core Needle Biopsies"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1634-6463","authenticated-orcid":false,"given":"Lucas Ant\u00f4nio F.","family":"Torres","sequence":"first","affiliation":[{"name":"Onofre Lopes University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L. R.","family":"Defante","sequence":"additional","affiliation":[{"name":"Department of Medicine, Redentor University Center, Itaperuna, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Fonseca","family":"Abreu","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, A.C. Camargo Cancer Center, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Melo","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1486-3480","authenticated-orcid":false,"given":"F\u00e1bio","family":"Medeiros de Azevedo","sequence":"additional","affiliation":[{"name":"Pathology Unit, Liga Norte Riograndense contra o C\u00e2ncer"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25977"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2025.100734"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.64997"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.09.001."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2013.13133"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14048"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1309\/5N2C-4N5X-CB8X-W8JL"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03939.x"},{"key":"e_1_3_2_10_2","unstructured":"Higgins JPT Thomas J Chandler J Cumpston M Li T Page MJ Welch VA. 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