{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:27:44Z","timestamp":1787740064773,"version":"build-2784847793"},"reference-count":39,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to evaluate the diagnostic utility of hypoxia inducible factor 1 subunit alpha (HIF1A) and carbonic anhydrase 9 (CA9) expression in differentiating between the 3 main types of pancreatic cystic neoplasms (PCNs): serous cystic neoplasms (SCNs), mucinous cystic neoplasms (MCNs), and intraductal papillary mucinous neoplasms (IPMNs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 72 surgically resected PCNs (35 SCNs, 23 MCNs, and 14 IPMNs). Immunohistochemical staining for HIF1A and CA9 was performed and scored semi-quantitatively. HIF1A and CA9 mRNA expression levels were also quantified using qRT-PCR. Statistical analyses correlated biomarker expression with detailed clinicopathological features and patient survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HIF1A mRNA expression was significantly higher in SCNs compared to MCNs and IPMNs (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Immunohistochemically, HIF1A protein was detected in 27 SCNs (77%) but was absent in all MCNs and IPMNs. In contrast, CA9 expression was frequently observed across all 3 PCN types (91% of SCNs, 96% of MCNs, and 86% of IPMNs) and showed no significant differential value.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HIF1A expression is a specific immunohistochemical marker for SCNs, reflecting underlying VHL\/HIF pathway dysregulation and aiding in their distinction from mucinous PCNs (MCNs and IPMNs). CA9 lacks diagnostic specificity. Incorporating HIF1A assessment into diagnostic algorithms could improve the preoperative classification and management of PCNs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10668969261425666","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:07:44Z","timestamp":1774274864000},"page":"1189-1200","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Utility of Hypoxia Inducible Factor 1 Subunit Alpha (HIF1A) in the Differential Diagnosis of Pancreatic Cystic Neoplasms"],"prefix":"10.1177","volume":"34","author":[{"given":"Cuiping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology, Qingxian People's Hospital, Cangzhou, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Chen","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Maternity and Child Health Care Hospital of Nantong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Tao","sequence":"additional","affiliation":[{"name":"Affiliated Maternity and Child Health Care Hospital of Nantong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8808-0814","authenticated-orcid":false,"given":"Mingming","family":"Yuan","sequence":"additional","affiliation":[{"name":"Affiliated Maternity and Child Health Care Hospital of Nantong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Ren","sequence":"additional","affiliation":[{"name":"Affiliated Maternity and Child Health Care Hospital of Nantong University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0262-SA"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-012-2072-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0348-z"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181f749d3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2012.04.004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0734"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182a18f48"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/20459"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12436"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181967992"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63971-5"},{"issue":"4","key":"e_1_3_2_13_2","first-page":"951","article-title":"Allelic deletion and mutation of the von Hippel-Lindau (VHL) tumor suppressor gene in pancreatic microcystic adenomas","volume":"151","author":"Vortmeyer AO","year":"1997","unstructured":"Vortmeyer AO, Lubensky IA, Fogt F, et al. Allelic deletion and mutation of the von Hippel-Lindau (VHL) tumor suppressor gene in pancreatic microcystic adenomas. Am J Pathol. 1997;151(4):951\u2013956.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.2"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000559"},{"key":"e_1_3_2_16_2","volume-title":"WHO Classification of Tumours: Digestive System Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2019","unstructured":"WHO Classification of Tumours Editorial Board. WHO Classification of Tumours: Digestive System Tumours. 5th ed. Vol 1. IARC; 2019.","edition":"5"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17917-8"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.259"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2017.04.003"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2014.12.007"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9287"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001570"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.10.011"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02352.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2016.08.005"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000000403"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.745001"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S246564"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13122015"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2023.07.016"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-1035-8"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-013-1116-z"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30084-X"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.09.028"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002543"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.91"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0513"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.4344"},{"key":"e_1_3_2_39_2","first-page":"2871289","article-title":"Glycopatterns and glycoproteins changes in MCN and SCN: a prospective cohort study","volume":"2019","author":"Wang Y","year":"2019","unstructured":"Wang Y, Sun Y, Feng J, et al. Glycopatterns and glycoproteins changes in MCN and SCN: a prospective cohort study. Biomed Res Int. 2019;2019:2871289.","journal-title":"Biomed Res Int"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01645-8"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261425666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969261425666","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261425666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:14:11Z","timestamp":1787739251000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969261425666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/10668969261425666"],"URL":"https:\/\/doi.org\/10.1177\/10668969261425666","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969261425666\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969261425666\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969261425666\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969261425666\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969261425666\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969261425666\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]}}}