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We describe the clinicopathologic characteristics of epidermoid cysts arising in the spleen in 13 patients, diagnosed between 1995 and 2025 at our institution. Most patients were diagnosed as young adults with a female predominance (11:2). The cysts were frequently identified as either incidental findings or in the setting of imaging performed for evaluation of abdominal pain. The size of the cysts was highly variable at presentation, ranging from 2.5\u2005cm to 16\u2005cm in greatest dimension. Unilocular and multilocular cysts were both seen and showed a similar benign course. In the patients who had complete surgical removal, there have been no known recurrences to date, consistent with a benign, self-limited process.<\/jats:p>","DOI":"10.1177\/10668969261435995","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:45:52Z","timestamp":1775807152000},"page":"1452-1457","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidermoid Cyst of the Spleen: A Single Institution Series"],"prefix":"10.1177","volume":"34","author":[{"given":"Harsimran","family":"Kaur","sequence":"first","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9274-0214","authenticated-orcid":false,"given":"Genevieve M.","family":"Crane","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198804000-00003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00446-3"},{"issue":"2","key":"e_1_3_2_4_2","first-page":"175","article-title":"Splenic epidermoid cyst\u2014a rare entity","volume":"8","author":"Rana AP","year":"2014","unstructured":"Rana AP, Kaur M, Singh P, Malhotra S, Kuka AS. 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