{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:38:19Z","timestamp":1792694299768,"version":"4.5.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Mucinous metaplasia in benign and malignant endometrial entities is well recognized. The mucinous epithelium may resemble the endocervix, coined as \u201cusual mucinous metaplasia,\u201d or may be gastric type epithelium consisting of bland epithelium with abundant pale cytoplasm, with or without goblet cells, so-called \u201cgastrointestinal metaplasia.\u201d Mostly described in premalignant and malignant endometrial entities (endometrial intraepithelial neoplasia\/atypical hyperplasia and carcinoma), rare examples of gastrointestinal metaplasia arising in benign endometrial polyps have been reported. In this paper, we report two additional postmenopausal patients with endometrial polyps showing gastrointestinal metaplasia with goblet cells. We performed molecular analysis, which revealed\n                    <jats:italic toggle=\"yes\">KRAS<\/jats:italic>\n                    mutation in codons 12\/13 in the first patient and codon 61 in the second patient. These associations raise the possibility that\n                    <jats:italic toggle=\"yes\">KRAS<\/jats:italic>\n                    mutations could be an early event in the endometrial carcinogenesis pathway, and that simple mucinous metaplasia of gastrointestinal type may represent an early precursor lesion.\n                  <\/jats:p>","DOI":"10.1177\/10668969261436007","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:14:31Z","timestamp":1776262471000},"page":"1603-1609","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Endometrial Gastrointestinal Mucinous Metaplasia With Goblet Cells and\n                    <i>KRAS<\/i>\n                    Mutation\u2014Report of Two Patients and Review of Literature"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3966-1263","authenticated-orcid":false,"given":"Stephanie","family":"Barak","sequence":"first","affiliation":[{"name":"Alpert Medical School of Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-6820","authenticated-orcid":false,"given":"Padmini A.","family":"Manrai","sequence":"additional","affiliation":[{"name":"Alpert Medical School of Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1371-9095","authenticated-orcid":false,"given":"M. Ruhul","family":"Quddus","sequence":"additional","affiliation":[{"name":"Alpert Medical School of Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000348"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1989.tb01598.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e318211d586"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001381"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2018.291278"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.15174"},{"issue":"2","key":"e_1_3_2_8_2","first-page":"63","article-title":"Endometrial carcinoma of the intestinal type. A first case report","volume":"2","author":"Berger G","year":"1984","unstructured":"Berger G, Fetissof F, Vitrey D, et al. Endometrial carcinoma of the intestinal type. A first case report. Appl Pathol. 1984;2(2):63\u201369.","journal-title":"Appl Pathol"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199507000-00009"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e31829ea82f"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.113"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.186"},{"issue":"5","key":"e_1_3_2_13_2","first-page":"2779","article-title":"Clinicopathological characteristics and KRAS mutation status of endometrial mucinous metaplasia and carcinoma","volume":"38","author":"Sung JY","year":"2018","unstructured":"Sung JY, Jung YY, Kim HS. Clinicopathological characteristics and KRAS mutation status of endometrial mucinous metaplasia and carcinoma. Anticancer Res. 2018;38(5):2779\u20132786.","journal-title":"Anticancer Res"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP69RBNUHHOJRI"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2025.156122"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199810000-00011"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261436007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969261436007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261436007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:43:12Z","timestamp":1792690992000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969261436007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/10668969261436007"],"URL":"https:\/\/doi.org\/10.1177\/10668969261436007","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]}}}