{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:38:24Z","timestamp":1792694304186,"version":"4.5.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"\n Background<\/jats:title>\n Signet-ring cell adenocarcinoma of the urinary bladder is a rare and aggressive malignancy. Complete colonic metaplasia of urinary bladder is exceedingly rare, with only 11 patients reported in English literature.<\/jats:p>\n <\/jats:sec>\n \n Presentation<\/jats:title>\n A 56-year-old woman presented with a 6-month history of voiding difficulty and hematuria. She underwent radical cystectomy with hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection, and was ultimately diagnosed as primary signet-ring cell adenocarcinoma of the urinary bladder. The entire bladder mucosa, including the ureteric mucosa, showed complete colonic metaplasia. Immunohistochemistry demonstrated a lower gastrointestinal-type immunophenotype, with positivity for KRT20 and CDX2.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n This report highlights an extremely rare instance of complete colonic metaplasia of the urothelium with subsequent development of signet-ring cell adenocarcinoma.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10668969261437127","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:45:02Z","timestamp":1775807102000},"page":"1630-1635","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Complete Colonic Metaplasia of the Urinary Bladder and Ureters With Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder: A Rare Occurrence"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0208-3108","authenticated-orcid":false,"given":"Saikat","family":"Mitra","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences Nagpur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshara","family":"Shangloo","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Nagpur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind A.","family":"Bhatkule","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Nagpur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiraz","family":"Akif","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences Nagpur"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"issue":"2","key":"e_1_3_2_2_2","first-page":"51","article-title":"Adenocarcinoma of the urinary bladder","volume":"3","author":"Dadhania V","year":"2015","unstructured":"Dadhania V, Czerniak B, Guo CC. Adenocarcinoma of the urinary bladder. Am J Clin Exp Urol. 2015;3(2):51\u201363.","journal-title":"Am J Clin Exp Urol"},{"issue":"2","key":"e_1_3_2_3_2","first-page":"223","article-title":"Signet-ring cell carcinoma of the urinary bladder","volume":"31","author":"SAPHIR O","year":"1955","unstructured":"SAPHIR O. Signet-ring cell carcinoma of the urinary bladder. 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