{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:38:23Z","timestamp":1792694303908,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Adenocarcinoma of mammary gland type of the vulva is an exceedingly rare malignancy, believed to arise from mammary-like vulvar glands. This report details such a malignancy in a 38-year-old female patient who presented with an ulcerated lesion on the left labia majora. Immunohistochemical analysis revealed robust expression of keratin 7, p16, GATA3, TRPS1, HER2, and androgen receptor, while negative expression for p63, p40, estrogen receptor, and progesterone receptor. Molecular profiling through targeted DNA\/RNA sequencing detected pathogenic missense variants in\n                    <jats:italic toggle=\"yes\">PIK3CA<\/jats:italic>\n                    (exon 10; c.1633G&gt;A; p.E545\u2005K; 50.70% VAF) and\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    (exon 6; c.659A&gt;G; p.Y220C; 61.50% VAF). Copy-number analysis showed\n                    <jats:italic toggle=\"yes\">ERBB2<\/jats:italic>\n                    amplification and gains in\n                    <jats:italic toggle=\"yes\">CDKN2A<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">CDK4<\/jats:italic>\n                    genes. Given the rarity of the tumor, it is crucial to distinguish it from morphological mimics to inform appropriate patient management. Treatment approaches are typically based on protocols for primary breast cancer, given the histological and biological similarities between these tumors and breast tissue.\n                  <\/jats:p>","DOI":"10.1177\/10668969261438130","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:41:17Z","timestamp":1775562077000},"page":"1664-1672","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Adenocarcinoma of Mammary Gland Type of the Vulva"],"prefix":"10.1177","volume":"34","author":[{"given":"Gauri","family":"Nakra","sequence":"first","affiliation":[{"name":"Homi Bhabha Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3978-0027","authenticated-orcid":false,"given":"Aishwarya","family":"Sharma","sequence":"additional","affiliation":[{"name":"Homi Bhabha Cancer Hospital and Research Centre (HBNI University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasheeda","family":"Mohamedali","sequence":"additional","affiliation":[{"name":"Homi Bhabha Cancer Hospital and Research Centre (HBNI University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Gedela","sequence":"additional","affiliation":[{"name":"Tata Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1814-792X","authenticated-orcid":false,"given":"Rahatdeep Singh","family":"Brar","sequence":"additional","affiliation":[{"name":"Homi Bhabha Cancer Hospital and Research Centre (HBNI University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Makkar","sequence":"additional","affiliation":[{"name":"Homi Bhabha Cancer Hospital and Research Centre (HBNI University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5363-3130","authenticated-orcid":false,"given":"Puneet","family":"Somal","sequence":"additional","affiliation":[{"name":"Homi Bhabha Cancer Hospital and Research Centre (HBNI University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilay","family":"Nishith","sequence":"additional","affiliation":[{"name":"Homi Bhabha Cancer Hospital and Research Centre (HBNI University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Raj","sequence":"additional","affiliation":[{"name":"Homi Bhabha Cancer Hospital and Research Centre (HBNI University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravikiransingh","family":"Pawar","sequence":"additional","affiliation":[{"name":"Homi Bhabha Cancer Hospital and Research Centre (HBNI University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5810-8733","authenticated-orcid":false,"given":"Sankalp","family":"Sancheti","sequence":"additional","affiliation":[{"name":"Homi Bhabha Cancer Hospital and Research Centre (HBNI University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Gulia","sequence":"additional","affiliation":[{"name":"Homi Bhabha Cancer Hospital and Research Centre (HBNI University)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"issue":"4","key":"e_1_3_2_2_2","first-page":"629","article-title":"Breast-like vulvar lesion with concurrent breast cancer: a case report and critical literature review","volume":"23","author":"Perrone G","year":"2009","unstructured":"Perrone G, Altomare V, Zagami M, et al. 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