{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:38:23Z","timestamp":1792694303420,"version":"4.5.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Rosai\u2013Dorfman disease is a rare histiocytic disorder that primarily affects lymph nodes but may present at extranodal sites. Breast involvement is exceptionally rare and often mimics malignancy on clinical and imaging studies, leading to diagnostic challenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the clinical, radiologic, and pathologic features of breast Rosai\u2013Dorfman disease and review management outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We retrospectively reviewed all instances of breast Rosai\u2013Dorfman disease diagnosed at our institution over a 14-month period. Clinical records, imaging studies, histopathology, treatment, and follow-up data were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of three patients were diagnosed with Rosai\u2013Dorfman disease of the breast. All three patients were women aged 22 to 71 years. Two presented with palpable breast masses, and one patient had a mass that was incidentally detected on chest computed tomography. Imaging demonstrated irregular masses categorized as Breast Imaging Reporting and Data System (BI-RADS) category 4\u20135, suspicious for carcinoma. Histopathologic examination showed dense lymphoplasmacytic infiltrates with histiocytes exhibiting emperipolesis and immunoreactivity for S100, CD68, and CD163, with negative CD1A staining. Two patients underwent excision, and one was managed conservatively. At follow-up, all patients remained disease-free without recurrence or systemic involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Breast Rosai\u2013Dorfman disease is a rare benign entity that closely mimics carcinoma both clinically and radiologically. Accurate diagnosis relies on histopathologic evaluation with immunohistochemistry. Management may range from observation to surgical excision depending on lesion size and symptoms. Awareness of this presentation is essential to prevent misdiagnosis and overtreatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10668969261438513","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:27:02Z","timestamp":1777908422000},"page":"1673-1678","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Rosai\u2013Dorfman Disease of the Breast: A Case Series and Review of the Literature"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1210-0600","authenticated-orcid":false,"given":"Alba Rebecca","family":"Hernandez Guzman","sequence":"first","affiliation":[{"name":"Temple University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6142-6688","authenticated-orcid":false,"given":"Romina","family":"Malerba","sequence":"additional","affiliation":[{"name":"Temple University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Rong","sequence":"additional","affiliation":[{"name":"Temple University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israh","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Temple University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Bains","sequence":"additional","affiliation":[{"name":"Temple University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalil","family":"Nasibli","sequence":"additional","affiliation":[{"name":"Temple University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-4104","authenticated-orcid":false,"given":"Maria F.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Temple University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"WHO classification of tumours: haematolymphoid tumours","author":"World Health Organization Classification of Tumours Editorial Board","year":"2022","unstructured":"World Health Organization Classification of Tumours Editorial Board. WHO classification of tumours: haematolymphoid tumours. 5th ed. Vol 11. International Agency for Research on Cancer; 2022.","edition":"5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2025.152513"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.55729\/2000-9666.1032"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2023.08.009"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57111167"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000000983"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001347"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.55"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4081\/rt.2014.5531"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16006"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261438513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969261438513","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261438513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:43:49Z","timestamp":1792691029000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969261438513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/10668969261438513"],"URL":"https:\/\/doi.org\/10.1177\/10668969261438513","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969261438513\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969261438513\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969261438513\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969261438513\/v1\/review1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]}}}