{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:07:30Z","timestamp":1788826050918,"version":"build-2803163510"},"reference-count":29,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    Elastic staining may aid in the diagnosis of pulmonary non-mucinous adenocarcinoma and its in situ lesions. This study evaluated elastic staining patterns and their diagnostic utility in a multi-cohort series. Elastic staining was performed in 120 lesions, including a principal cohort (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200960), an internal validation cohort (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200930), an external validation cohort (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200930), and an interobserver agreement cohort (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200940). Staining patterns were analyzed and their impact on diagnostic accuracy was assessed. Four elastic staining patterns were identified: a point-and-linear pattern, an intensified point-and-linear pattern, a disorderly thickened and recoiled pattern with continuous and discontinuous variants, and a decreased or disappeared pattern. All adenocarcinoma in situ lesions and the in situ components of minimally invasive adenocarcinoma and invasive adenocarcinoma demonstrated the continuous disorderly thickened and recoiled pattern. The decreased or disappeared pattern was observed in the majority of invasive adenocarcinomas and in all invasive components of minimally invasive adenocarcinoma, whereas a subset of invasive adenocarcinomas exhibited the discontinuous variant associated with extensive carcinomatous collapse. Non-neoplastic lesions displayed a point-and-linear pattern, with an intensified point-and-linear pattern observed in regions of iatrogenic or mechanical collapse. No significant differences were identified between validation cohorts (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&gt;\u20090.05). Diagnostic accuracy and histologic identification improved with the use of elastic staining among both trainee and general pathologists, and interobserver agreement was high (Kappa\u2009=\u20090.945). Overall, elastic staining represents a useful adjunct for improving diagnostic accuracy and histologic classification of pulmonary non-mucinous adenocarcinoma and its in situ lesions.\n                  <\/jats:p>","DOI":"10.1177\/10668969261439152","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:32:41Z","timestamp":1778934761000},"page":"1727-1736","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Elastic Staining Features in Pulmonary Non-Mucinous Adenocarcinoma and Associated In Situ Lesions: Diagnostic Implications"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3823-7615","authenticated-orcid":false,"given":"Jun","family":"Zhou","sequence":"first","affiliation":[{"name":"the Second People's Hospital of Yibin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6345-8914","authenticated-orcid":false,"given":"Xue","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Shen","sequence":"additional","affiliation":[{"name":"Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Nanjing University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3775"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2020.02.005"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2016.06.07"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134569"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.14.2817"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2019.07.005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15899"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.01.005"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14537"},{"issue":"7","key":"e_1_3_2_12_2","article-title":"Evaluating three elastic-fiber staining methods for detecting visceral pleural invasion in lung adenocarcinoma patients","volume":"67","author":"Xie LW","year":"2021","unstructured":"Xie LW, Wang J. Evaluating three elastic-fiber staining methods for detecting visceral pleural invasion in lung adenocarcinoma patients. Clin Lab. 2021;67(7).","journal-title":"Clin Lab"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2024.108060"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000451"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.09.017"},{"key":"e_1_3_2_16_2","first-page":"64","volume-title":"WHO classification of tumors: thoracic tumors","author":"Cooper W","year":"2021","unstructured":"Cooper W, Bubendorf L, Kadota K, et al. Invasive non-mucinous adenocarcinoma of the lung. In: TWCoTE B, ed. WHO classification of tumors: thoracic tumors. 5th ed. 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