{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:08:23Z","timestamp":1788800903750,"version":"build-2803163510"},"reference-count":31,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Hospital Level Talent Project of Afliated Zhoupu Hospital of Shanghai University of Medicine and Health Sciences","award":["ZPRC-2023A-07"],"award-info":[{"award-number":["ZPRC-2023A-07"]}]},{"name":"Shanghai Pudong New Area Foundation for Development of Science and Technology","award":["PKJ2025-Y43"],"award-info":[{"award-number":["PKJ2025-Y43"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    Serous tumors of the testis and paratestis are rare neoplasms originating from M\u00fcllerian duct epithelium, exhibiting histological features analogous to their ovarian counterparts, predominantly manifesting as serous borderline tumors and low-grade serous carcinomas. Definitive diagnosis of these tumors requires histopathological examination and immunohistochemical profiles to confirm M\u00fcllerian differentiation. This study reports the first documented\n                    <jats:italic toggle=\"yes\">NRAS p.Q61R<\/jats:italic>\n                    mutation as a likely pathogenic variant (Class II) and a\n                    <jats:italic toggle=\"yes\">BRCA2<\/jats:italic>\n                    variant of uncertain significance (Class III) in a tunica vaginalis micropapillary serous borderline tumor with microinvasive low-grade serous carcinoma. While\n                    <jats:italic toggle=\"yes\">NRAS<\/jats:italic>\n                    mutations are infrequently observed in ovarian serous tumors, their presence in this context suggested potential shared oncogenic pathways between male and female M\u00fcllerian-type neoplasms. Notably, the\n                    <jats:italic toggle=\"yes\">NRAS p.Q61R<\/jats:italic>\n                    variant was classified as Class II and may be associated with malignant progression from borderline tumors to invasive carcinoma. These findings underscore the need for long-term surveillance and molecular investigations to clarify tumor behavior, recurrence risks, and therapeutic targets in such rare entities.\n                  <\/jats:p>","DOI":"10.1177\/10668969261439280","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:13:06Z","timestamp":1776953586000},"page":"1874-1880","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Micropapillary Serous Borderline Tumor With Microinvasive Low-Grade Serous Carcinoma of the Tunica Vaginalis Harboring\n                    <i>NRAS p.Q61R<\/i>\n                    Mutation: Expanding the Molecular Spectrum of Paratesticular M\u00fcllerian-Type Tumors"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-7081","authenticated-orcid":false,"given":"Baoling","family":"Xing","sequence":"first","affiliation":[{"name":"Affiliated Zhoupu Hospital of Shanghai University of Medicine and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3280-6244","authenticated-orcid":false,"given":"Xiaoying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Zhoupu Hospital of Shanghai University of Medicine and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5760-9621","authenticated-orcid":false,"given":"Hui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Affiliated Zhoupu Hospital of Shanghai University of Medicine and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3758-4893","authenticated-orcid":false,"given":"Xia","family":"Gu","sequence":"additional","affiliation":[{"name":"Affiliated Zhoupu Hospital of Shanghai University of Medicine and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2020.06.006"},{"issue":"11","key":"e_1_3_3_3_2","first-page":"5011","article-title":"Borderline serous papillary tumour of the testis: a case report and review of the literature","volume":"32","author":"Ibrahim AS","year":"2012","unstructured":"Ibrahim AS, Li C, MS A-J. Borderline serous papillary tumour of the testis: a case report and review of the literature. Anticancer Res. 2012;32(11):5011\u20135013.","journal-title":"Anticancer Res"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2022.06.028"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-015-0342-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/10668969241232702"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/10935266231221029"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13691-023-00608-8"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02017.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1979.tb03584.x"},{"issue":"8","key":"e_1_3_3_11_2","first-page":"774","article-title":"Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors","volume":"11","author":"Iczkowski KA","year":"1998","unstructured":"Iczkowski KA, Bostwick DG, Roche PC, et al. Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. Mod Pathol. 1998;11(8):774\u2013779.","journal-title":"Mod Pathol"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000326"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001219"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199512000-00003"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14661"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12630"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13261"},{"key":"e_1_3_3_18_2","first-page":"5419707","article-title":"KRAS mutation in serous borderline tumor of the testis: report of a case and review of the literature","volume":"2020","author":"Bouri S","year":"2020","unstructured":"Bouri S, No\u00ebl JC, Catteau X, et al. KRAS mutation in serous borderline tumor of the testis: report of a case and review of the literature. Case Rep Urol. 2020;2020:5419707.","journal-title":"Case Rep Urol"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1292"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.03.019"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2025.06.022"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.5495"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2023.12.004"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000444"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5438"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.08.021"},{"key":"e_1_3_3_27_2","volume-title":"Classi\ufb01cation of Tumors Editorial Board. Female Genital Tumors. WHO Classi\ufb01cation of Tumors Series","author":"World Health Organization (WHO)","year":"2020","unstructured":"World Health Organization (WHO). Classi\ufb01cation of Tumors Editorial Board. Female Genital Tumors. WHO Classi\ufb01cation of Tumors Series. 5th ed. International Agency for Research on Cancer; 2020, Vol. 4.","edition":"5"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-3872"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54140-1"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2024.05.038"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.24154"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.10.033"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261439280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969261439280","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261439280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:17:02Z","timestamp":1788797822000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969261439280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/10668969261439280"],"URL":"https:\/\/doi.org\/10.1177\/10668969261439280","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]}}}