{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:07:33Z","timestamp":1788829653557,"version":"build-2803163510"},"reference-count":24,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100018990","name":"Alfaisal University","doi-asserted-by":"publisher","award":["IRG No.22311"],"award-info":[{"award-number":["IRG No.22311"]}],"id":[{"id":"10.13039\/501100018990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study assessed the potential utility of GATA3, cyclin D1, KRT20, and GLUT1 immunohistochemistry (IHC) markers for diagnosing renal epithelial tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis was conducted on all eligible specimens (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200995) diagnosed at our institution between 2014 and 2024. IHC was done and the staining intensity and distribution of selected IHC markers were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 95 specimens, 26% were clear cell renal cell carcinoma, 21% were chromophobe RCC, and 17% were papillary RCC. Less frequent subtypes included TFE3-rearranged RCC, clear cell papillary renal cell tumor (CCPRT), papillary renal neoplasm with reverse polarity (PRNRP), and eosinophilic solid and cystic RCC (ESC-RCC). Clear cell RCC and CCPRT were consistently positive for cyclin D1 and GLUT1, and negative for GATA3\/KRT20. CCPRT showed strong, diffuse GLUT1, unlike the limited staining in papillary RCC. PRNRP was positive for GATA3, cyclin D1, and GLUT1, and negative for KRT20. While chromophobe RCC exhibited variable GATA3 and GLUT1 expression with weak to moderate cyclin D1 positivity, oncocytomas were strong cyclin D1 positive, with negative GATA3, KRT20, and GLUT1. All 3 ESC-RCC specimens were KRT20 positive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings validate many previously reported observations and characterize adjunctive patterns of these less commonly used markers across renal tumor subtypes. It suggests GATA3 as a potential diagnostic tool for PRNRP, while GLUT1 demonstrates differential expression patterns for papillary RCC and CCPRT, aiding in distinguishing papillary renal tumors. Similarly, cyclin D1 appears to be a valuable adjunct in differentiating oncocytoma from chromophobe RCC. Also, KRT20 shows high specificity for ESC-RCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10668969261442121","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:38:24Z","timestamp":1782391104000},"page":"1759-1766","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Value of Immunohistochemical Markers GATA3, Cyclin D1, KRT20, and GLUT1 in Renal Neoplasms"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9225-0274","authenticated-orcid":false,"given":"Muhammad Abrar","family":"Barakzai","sequence":"first","affiliation":[{"name":"College of Medicine, Alfaisal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3347-6796","authenticated-orcid":false,"given":"Shoukat Ali","family":"Arain","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7983-3405","authenticated-orcid":false,"given":"Nasir Ali","family":"Afsar","sequence":"additional","affiliation":[{"name":"Qassim University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5266-3063","authenticated-orcid":false,"given":"Yara Obaeda","family":"Alsouss","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1755-163X","authenticated-orcid":false,"given":"Turki","family":"Al-Hussain","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University"},{"name":"King Faisal Specialist Hospital and Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Urinary and Male Genital Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2022","unstructured":"WHO Classification of Tumours Editorial Board. Urinary and Male Genital Tumours. 5th ed. International Agency for Research on Cancer; 2022.","edition":"5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16101856"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.06.016"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.930296"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01018-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.21"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122648"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2014.12.014"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.5483\/bmbrep.2017.50.3.189"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2022.02.009"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-020-00253-3"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009855"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2023.104860"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.21037\/tau-23-518"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001773"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001288"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2021.153611"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14816"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3892\/br.2021.1455"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810587"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.01.016"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14663"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13395"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261442121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969261442121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261442121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:16:54Z","timestamp":1788826614000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969261442121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/10668969261442121"],"URL":"https:\/\/doi.org\/10.1177\/10668969261442121","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]}}}