{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:31:59Z","timestamp":1793233919496,"version":"4.5.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:p>\n                    Squamous cell carcinoma (SCC) of the renal pelvis is an exceptionally rare and aggressive malignancy,\n                    <jats:italic toggle=\"yes\">commonly<\/jats:italic>\n                    associated with long-standing nephrolithiasis and chronic inflammation. We report 2 renal pelvis SCCs arising in the setting of decades-long renal stone disease, highlighting clinicopathologic features, immunophenotype, and molecular alterations. Both tumors showed extensive squamous metaplasia, moderately differentiated SCC with comedo-type necrosis, aggressive local invasion, and poor clinical outcome. Immunohistochemically, tumors demonstrated diffuse p63\/p40\/keratin\n                    <jats:italic toggle=\"yes\">5\/6<\/jats:italic>\n                    expression, aberrant p53 patterns, p16 negativity, and strikingly high PD-L1 expression (CPS 85 and 72.5). Molecular analysis revealed\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    alterations in both tumors and a\n                    <jats:italic toggle=\"yes\">TERT<\/jats:italic>\n                    promoter mutation (C228T) in one tumor, which was associated with early distant metastases. These findings support the concept that renal pelvis SCC represents a biologically distinct, inflammation-driven carcinoma with adverse prognosis, limited response to conventional therapy, and potential relevance of immune checkpoint inhibition.\n                  <\/jats:p>","DOI":"10.1177\/10668969261449478","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:09:54Z","timestamp":1780474194000},"page":"2062-2066","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Renal Pelvis Squamous Cell Carcinoma Arising in the Setting of Long-Standing Nephrolithiasis: Clinicopathologic and Molecular Insights"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1580-2926","authenticated-orcid":false,"given":"Ahmet","family":"Erba\u011fci","sequence":"first","affiliation":[{"name":"Istanbul Medeniyet University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0131d\u0131ka \u015eeyma","family":"\u00d6zkanli","sequence":"additional","affiliation":[{"name":"Istanbul Medeniyet University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevil","family":"Albayrak","sequence":"additional","affiliation":[{"name":"Istanbul Medeniyet University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilker Nihat","family":"\u00d6kten","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, G\u00f6ztepe Prof. Dr. S\u00fcleyman Yal\u00e7\u0131n City Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1933-9824","authenticated-orcid":false,"given":"G\u00f6zde","family":"Kir","sequence":"additional","affiliation":[{"name":"Istanbul Medeniyet University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.03.033"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2011.08.009"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)68899-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.09.010"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)43116-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2015.03.005"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes12030333"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2020.08.001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0142(19970601)79:11<2178::aid-cncr16>3.0.co;2-t"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2011.92"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910640503"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2023.09.001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000523"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00561-4"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261449478","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969261449478","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261449478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:47:49Z","timestamp":1793231269000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969261449478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1177\/10668969261449478"],"URL":"https:\/\/doi.org\/10.1177\/10668969261449478","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]}}}