{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:26:28Z","timestamp":1793568388110,"version":"4.5.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PNRR M4.C2 THE - CUP: I53C22000780001"],"award-info":[{"award-number":["PNRR M4.C2 THE - CUP: I53C22000780001"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:p>\n                    Mucinous cystadenocarcinoma of the breast is rare and has been recently classified as a distinct entity in the fifth edition of the WHO Classification of Tumors. Here, we present a 47-year-old woman with a history of NST carcinoma in her right breast who subsequently developed a lump in the right chest wall close to the breast implant. Immunohistochemical analysis showed negativity for keratin 20 and CDX2, and positivity for mammaglobin, GCDFP15 and TRPS1 with a triple-negative phenotype. The diagnosis of primary mucinous cystadenocarcinoma of the breast was finally established. Next-generation sequencing identified likely pathogenetic mutations specifically in\n                    <jats:italic toggle=\"yes\">AKT1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">EGFR<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">FANCA<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">BCL10<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">CTCF<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">RUNX1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">RP1-34H18.1::NAV3<\/jats:italic>\n                    gene fusion, making this as the first reported example in the literature harboring an\n                    <jats:italic toggle=\"yes\">RP1-34H18.1::NAV3<\/jats:italic>\n                    gene fusion identified within a comprehensive RNA-based molecular analysis, representing the 49\n                    <jats:sup>th<\/jats:sup>\n                    reported patient worldwide.\n                  <\/jats:p>","DOI":"10.1177\/10668969261457877","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:33:04Z","timestamp":1783420384000},"page":"2182-2191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mucinous Cystadenocarcinoma of the Breast: A Clinicopathologic and Molecular Case Report With Literature Review"],"prefix":"10.1177","volume":"34","author":[{"given":"Roberta","family":"Iozzo","sequence":"first","affiliation":[{"name":"University of Pisa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8154-3730","authenticated-orcid":false,"given":"Eugenia","family":"Belcastro","sequence":"additional","affiliation":[{"name":"University of Pisa Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7069-7980","authenticated-orcid":false,"given":"Giuseppe Nicol\u00f2","family":"Fanelli","sequence":"additional","affiliation":[{"name":"University of Pisa"},{"name":"Pisa University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Fanelli","sequence":"additional","affiliation":[{"name":"Pisa University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3037-0474","authenticated-orcid":false,"given":"Aldo","family":"Pastore","sequence":"additional","affiliation":[{"name":"Pisa Science Foundation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1075-4319","authenticated-orcid":false,"given":"Paolo","family":"Aretini","sequence":"additional","affiliation":[{"name":"Pisa Science Foundation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Rossetti","sequence":"additional","affiliation":[{"name":"Pisa University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8195-9445","authenticated-orcid":false,"given":"Antonio Giuseppe","family":"Naccarato","sequence":"additional","affiliation":[{"name":"University of Pisa"},{"name":"Pisa University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4862-0845","authenticated-orcid":false,"given":"Cristian","family":"Scatena","sequence":"additional","affiliation":[{"name":"University of Pisa"},{"name":"Pisa University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199806000-00006"},{"key":"e_1_3_2_3_2","volume-title":"Breast Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2019","unstructured":"WHO Classification of Tumours Editorial Board. Breast Tumours. International Agency for Research on Cancer; 2019, (WHO classification of tumours series, 5th ed.; vol. 2)."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.15073"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.170"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.09.038"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605673"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.5.5485"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04869"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1011183421477"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188715"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.04.077"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03946-z"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1462810"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000533"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0210-y"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-18608-8"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000203"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201404134"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261457877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969261457877","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261457877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T20:49:16Z","timestamp":1793566156000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969261457877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1177\/10668969261457877"],"URL":"https:\/\/doi.org\/10.1177\/10668969261457877","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]}}}