{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:34:09Z","timestamp":1793230449205,"version":"4.5.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Basic Research Program of Jinhua municipal central hospital","award":["JY2021-6-06"],"award-info":[{"award-number":["JY2021-6-06"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:p>\n                    Intracranial mesenchymal tumor with\n                    <jats:italic toggle=\"yes\">EWSR1<\/jats:italic>\n                    ::\n                    <jats:italic toggle=\"yes\">CREM<\/jats:italic>\n                    fusion represents a rare molecular subtype of\n                    <jats:italic toggle=\"yes\">FET<\/jats:italic>\n                    ::\n                    <jats:italic toggle=\"yes\">CREB<\/jats:italic>\n                    fusion-positive neoplasms, provisionally recognized in the 2021 WHO Classification of Tumors of the Central Nervous System. These non-meningeal, primary intracranial tumors exhibit a broad histomorphologic spectrum and uncertain histogenesis; outcome data remain limited, yet their distinctive localization and unique histology warrant continued study. We analyzed 26\n                    <jats:italic toggle=\"yes\">EWSR1<\/jats:italic>\n                    ::\n                    <jats:italic toggle=\"yes\">CREM<\/jats:italic>\n                    fusion-positive patients, comprising 25 from the literature and one new patient\u2014a 60-year-old woman with a history of breast carcinoma who presented with a right frontal mass. Histology demonstrated classic stellate\/spindle cell morphology, abundant myxoid stroma, and positivity for EMA, CD99, desmin, and CD163. Following gross-total resection, she remains disease-free at 17 months, representing the second-oldest reported patient to date.\n                  <\/jats:p>","DOI":"10.1177\/10668969261457882","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:16:05Z","timestamp":1780996565000},"page":"2144-2150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intracranial Mesenchymal Tumor With Rare\n                    <i>EWSR1<\/i>\n                    ::\n                    <i>CREM<\/i>\n                    Gene Fusion in an Older Adult Woman: A Case Report and Review of the Literature"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-8464","authenticated-orcid":false,"given":"Angcheng","family":"Li","sequence":"first","affiliation":[{"name":"Zhejiang University School of Medicine, Affiliated Jinhua Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglan","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine, Affiliated Jinhua Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine, Affiliated Jinhua Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Hua","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine, Affiliated Jinhua Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1813-3781","authenticated-orcid":false,"given":"Lixia","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine, Affiliated Jinhua Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-020-00359-x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-024-01721-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000788"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12504"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nly039"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.02.107"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000501695"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.07.015"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyaa357"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12900"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12737"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12918"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12740"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2176\/jns-nmc.2021-0385"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.13010"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1203994"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12877"},{"issue":"1","key":"e_1_3_2_19_2","first-page":"41","article-title":"Intracranial mesenchymal tumours with FET::CREB fusion: a clinicopathological analysis of six cases","volume":"54","author":"Hu PZ","year":"2025","unstructured":"Hu PZ, Cui L, Wang WW, Wu XY, Li WC, Zhang HY. Intracranial mesenchymal tumours with FET::CREB fusion: a clinicopathological analysis of six cases. Zhonghua Bing Li Xue Za Zhi. 2025;54(1):41-45.","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2176\/jns-nmc.2024-0103"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261457882","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969261457882","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261457882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:20:54Z","timestamp":1793229654000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969261457882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1177\/10668969261457882"],"URL":"https:\/\/doi.org\/10.1177\/10668969261457882","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/10668969261457882\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969261457882\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/10668969261457882\/v2\/response1","asserted-by":"object"}]},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]}}}