{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:03:31Z","timestamp":1790269411996,"version":"4.1.0"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"abstract":"<jats:p>\n                    The uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare mesenchymal tumor of the uterus. Morphological patterns can show sheets, cords, and trabeculae that are similar to those seen in ovarian sex cord-stromal tumors. Immunohistochemically, they exhibit a polyphenotypic variable pattern, including epithelial, myoid, and sex cord lineage as well as hormone receptors. We report a female patient with a UTROSCT harboring a\n                    <jats:italic toggle=\"yes\">GREB1::NCOA2<\/jats:italic>\n                    fusion that demonstrated a diffuse, strong positivity with chromogranin, synaptophysin, and CD56. INSM1 was performed to rule out true neuroendocrine differentiation. While neuroendocrine marker expression is rare in UTROSCT, this report adds to the limited literature describing this unusual immunoprofile, particularly in the context of\n                    <jats:italic toggle=\"yes\">GREB1<\/jats:italic>\n                    rearrangements. This study remains important to highlight the inclusion of this type of immunohistochemical staining in the spectrum of features UTROSCT can represent. Recent systematic review evidence suggests that\n                    <jats:italic toggle=\"yes\">GREB1<\/jats:italic>\n                    -rearranged UTROSCTs may represent a biologically and clinically distinct subset from\n                    <jats:italic toggle=\"yes\">ESR1<\/jats:italic>\n                    -rearranged tumors, with differences in clinicopathological features and molecular characteristics.\n                  <\/jats:p>","DOI":"10.1177\/10668969261457884","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:00:33Z","timestamp":1790074833000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Uterine Tumor Resembling Ovarian Sex Cord Tumor With\n                    <i>GREB1::NCOA2<\/i>\n                    Fusion and Neuroendocrine Marker Expression: A Case Report and Literature Review"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6667-9649","authenticated-orcid":false,"given":"Fatma Lina","family":"Emiroglu","sequence":"first","affiliation":[{"name":"Zucker School of Medicine at Hofstra\/Northwell"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9754-8680","authenticated-orcid":false,"given":"Bogdan","family":"Firsov","sequence":"additional","affiliation":[{"name":"Zucker School of Medicine at Hofstra\/Northwell"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-1234","authenticated-orcid":false,"given":"Saroja Devi","family":"Geetha","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudarshana","family":"Roychoudhury","sequence":"additional","affiliation":[{"name":"Zucker School of Medicine at Hofstra\/Northwell"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahyna","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Zucker School of Medicine at Hofstra\/Northwell"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Khutti","sequence":"additional","affiliation":[{"name":"Zucker School of Medicine at Hofstra\/Northwell"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6275-8069","authenticated-orcid":false,"given":"Cao","family":"Jin","sequence":"additional","affiliation":[{"name":"Zucker School of Medicine at Hofstra\/Northwell"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"issue":"1","key":"e_1_3_2_2_2","first-page":"53","article-title":"Heterologous mesodermal tumor of the uterus\u00b8 report of a neoplasm resembling a granulosa cell tumor","volume":"21","author":"Morehead RP","year":"1945","unstructured":"Morehead RP, Bowman MC. Heterologous mesodermal tumor of the uterus\u00b8 report of a neoplasm resembling a granulosa cell tumor. Am J Pathol. 1945;21(1):53\u201361.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/66.3.512"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198004010-00006"},{"key":"e_1_3_2_5_2","volume-title":"Female genital tumours","author":"WHO Classification of Tumours Editorial Board","year":"2020","unstructured":"WHO Classification of Tumours Editorial Board. Female genital tumours. 5th ed. IARC Press; 2020."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.07.050"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800475"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001153"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001265"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001348"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22518"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000849"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000633"},{"issue":"2","key":"e_1_3_2_14_2","first-page":"180","article-title":"Malignant mixed M\u00fcllerian tumor with small cell neuroendocrine differentiation: a case report and review of the literature","volume":"35","author":"Toptas T","year":"2014","unstructured":"Toptas T, Tasova-Yildirim G, Karaveli S, Simsek T. Malignant mixed M\u00fcllerian tumor with small cell neuroendocrine differentiation: a case report and review of the literature. Eur J Gynaecol Oncol. 2014;35(2):180\u2013184.","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14639"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2019.02.003"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261457884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969261457884","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261457884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:22:47Z","timestamp":1790266967000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969261457884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":15,"alternative-id":["10.1177\/10668969261457884"],"URL":"https:\/\/doi.org\/10.1177\/10668969261457884","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]},"article-number":"10668969261457884"}}