{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:20:29Z","timestamp":1787649629318,"version":"build-2736575974"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"abstract":"\n Atypical lipomatous tumor\/well-differentiated liposarcoma (ALT\/WDLPS) is a low-grade adipocytic neoplasm composed of mature adipocytes with at least focal nuclear atypia in adipocytes and stromal cells. The terms \u201catypical lipomatous tumor\u201d and \u201cwell-differentiated liposarcoma\u201d are site-dependent terms for the same morphological and genetic entity. Amplification of\n MDM2<\/jats:italic>\n and\/or\n CDK4 is<\/jats:italic>\n almost always present and is a defining molecular feature. It usually arises in deep soft tissue. Primary head-and-neck involvement is rare, and salivary gland tumors are exceptionally uncommon. Only a few salivary gland tumors have been reported and accurate diagnosis may be challenging because they can mimic benign lipomatous lesions. ALT lacks metastatic potential unless dedifferentiation occurs, but it carries a significant risk of local recurrence. Careful histology plus\n MDM2<\/jats:italic>\n gene testing improves diagnostic accuracy. We report a 59-year-old man presenting with a recurrent parotid mass 7 years after a lipoma excision at an outside facility. Imaging showed involvement of both superficial and deep lobes of the left parotid gland. The facial nerve was preserved during surgery, and the postoperative course was uneventful. Histologic examination of the reexcision specimen showed mature adipose tissue with adipocyte size variation and focal atypia within fibrous septa; fluorescence in situ hybridization confirmed\n MDM2<\/jats:italic>\n amplification, establishing ALT. This case report aims to highlight the diagnostic challenges of ALT in uncommon locations such as the parotid gland and to evaluate strategies for accurate recognition and effective management, with emphasis on avoiding misdiagnosis and ensuring complete surgical excision.\n <\/jats:p>","DOI":"10.1177\/10668969261458405","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:57:16Z","timestamp":1784728636000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Atypical Lipomatous Tumor\/Well-Differentiated Liposarcoma of the Salivary Gland and Its Diagnostic Challenges: A Case Report and Literature Review"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3789-0265","authenticated-orcid":false,"given":"Breera","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Mississippi Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1836-8948","authenticated-orcid":false,"given":"Javaria","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Mississippi Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1258-9747","authenticated-orcid":false,"given":"Youssef","family":"Al Hmada","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Mississippi Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Mississippi Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/483154"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23311"},{"key":"e_1_3_2_4_2","volume-title":"WHO Classification of Head and Neck Tumours. 5th ed","author":"WHO Classification of Tumours Editorial Board","year":"2024","unstructured":"WHO Classification of Tumours Editorial Board. WHO Classification of Head and Neck Tumours. 5th ed. International Agency for Research on Cancer; 2024."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880340091016"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1995.tb01162.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000027625.79334.F5"},{"issue":"10","key":"e_1_3_2_8_2","article-title":"Atypical lipomatous tumor\/well-differentiated liposarcoma of the parotid gland: Report and literature review","volume":"88","author":"Mahmood U","year":"2009","unstructured":"Mahmood U, Nguyen JD, Chang J, et al. Atypical lipomatous tumor\/well-differentiated liposarcoma of the parotid gland: Report and literature review. Ear Nose Throat J. 2009;88(10):E10-E16. PMID:19826985","journal-title":"Ear Nose Throat J"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00957030"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197912000-00004"},{"issue":"4","key":"e_1_3_2_11_2","first-page":"258","article-title":"Well-differentiated liposarcoma (atypical lipomatous tumors)","volume":"18","author":"Laurino L","year":"2001","unstructured":"Laurino L, Furlanetto A, Orvieto E, Dei Tos AP. Well-differentiated liposarcoma (atypical lipomatous tumors). Semin Diagn Pathol. 2001;18(4):258-262. PMID:11757865.","journal-title":"Semin Diagn Pathol"},{"key":"e_1_3_2_12_2","volume-title":"WHO classification of tumours of soft tissue and bone","author":"World Health Organization","year":"2002","unstructured":"World Health Organization. WHO classification of tumours of soft tissue and bone. 3rd ed. IARC; 2002."},{"key":"e_1_3_2_13_2","volume-title":"Soft tissue and bone tumours","author":"WHO Classification of Tumours Editorial Board","year":"2020","unstructured":"WHO Classification of Tumours Editorial Board. Soft tissue and bone tumours. 5th ed. International Agency for Research on Cancer; 2020, WHO Classification of Tumours Series, vol 3."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2018.01.013"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2019.02.006"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2009.08.003"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261458405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969261458405","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261458405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:39:12Z","timestamp":1787647152000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969261458405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":15,"alternative-id":["10.1177\/10668969261458405"],"URL":"https:\/\/doi.org\/10.1177\/10668969261458405","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"article-number":"10668969261458405"}}