{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:20:57Z","timestamp":1787649657177,"version":"build-2736575974"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Fetal lung adenocarcinoma is a rare malignant lung tumor, constituting about 0.1% to 0.5% of primary lung tumors. It is categorized into two types based on histopathological and clinical differences: low-grade and high-grade types. The primary distinction is the formation of morula bodies and \u03b2-catenin, P53 expression. High-grade fetal lung adenocarcinoma is more common in middle-aged to elderly men with heavy smoking history; it is highly malignant and often diagnosed with regional lymph node or distant metastasis. Recent literature mainly consists of case reports, focusing on advanced-stage high-grade type, with few reports concerning early-stage high-grade type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>\n                      This article reviews the treatment journey of a rare early-stage high-grade fetal lung adenocarcinoma patient. The patient was a non-smoking elderly woman with no respiratory symptoms. A chest CT scan showed a nodule in the lower left lung, with normal tumor markers. Single-port thoracoscopic left lower lung wedge resection was performed, and intraoperative frozen pathology indicated invasive lung adenocarcinoma, leading to lobectomy and mediastinal lymphadenectomy. Postoperative pathology identified high-grade fetal lung adenocarcinoma, with pathological stage pT1bN0 IA2. We present the first report of early-stage high-grade fetal lung adenocarcinoma with\n                      <jats:italic toggle=\"yes\">KRAS<\/jats:italic>\n                      mutation. At 17-month follow-up the patient remains disease-free without adjuvant therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diagnosing fetal lung adenocarcinoma, an independent subtype of lung adenocarcinoma, relies on pathological evaluation, and the standard treatment is surgical resection. Since this disease is rare, early-stage high-grade fetal lung adenocarcinoma is even rarer, requiring more research to find the best treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10668969261463674","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:49:37Z","timestamp":1785246577000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Early-Stage High-Grade Fetal Lung Adenocarcinoma With\n                    <i>KRAS<\/i>\n                    Mutation: A Rare Presentation and Literature Review"],"prefix":"10.1177","author":[{"given":"Baoxiang","family":"Pei","sequence":"first","affiliation":[{"name":"Institute of Thoracic Tumor Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiliang","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Thoracic Tumor Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5868-2418","authenticated-orcid":false,"given":"Fen","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute of Thoracic Tumor Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1293534"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.7.4.299"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.5603\/ARM.a2021.0085"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318206a221"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/10668969231188890"},{"key":"e_1_3_3_7_2","first-page":"57","article-title":"Comprehensive review of fetal adenocarcinoma of the lung","volume":"9","author":"Ricaurte LM","year":"2018","unstructured":"Ricaurte LM, Arrieta O, Zatarain-Barr\u00f3n ZL, Cardona AF. Comprehensive review of fetal adenocarcinoma of the lung. Lung Cancer (Auckl). 2018;9(1):57\u201363.","journal-title":"Lung Cancer (Auckl)"},{"issue":"3","key":"e_1_3_3_8_2","first-page":"1587","article-title":"Well-differentiated fetal adenocarcinoma of the lung: clinicopathologic features of 45 cases in China","volume":"11","author":"Zhang TM","year":"2018","unstructured":"Zhang TM, Lu BH, Cai YR, et al. Well-differentiated fetal adenocarcinoma of the lung: clinicopathologic features of 45 cases in China. Int J Clin Exp Pathol. 2018;11(3):1587\u20131598.","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-24-124"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181ceef74"},{"key":"e_1_3_3_11_2","volume-title":"Pleuropulmonary blastoma","author":"Mlika M","year":"2025","unstructured":"Mlika M, Anjum F, El Mezni F. Pleuropulmonary blastoma. 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