{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:02:58Z","timestamp":1790100178974,"version":"4.0.1"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["Project No. 124S114"],"award-info":[{"award-number":["Project No. 124S114"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malignant serous effusions may be the first manifestation of an underlying malignancy, and accurate primary-site attribution is essential. However, distinguishing M\u00fcllerian carcinoma, breast carcinoma, and mesothelioma in effusion cytology remains a challenge because of overlapping immunophenotypes. We evaluated SOX17 and TRPS1 in this setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A multicenter retrospective cohort including 650 tissue specimens (300 breast carcinomas, 300 M\u00fcllerian tumors, and 50 mesothelial lesions) and 150 malignant serous effusion cell blocks was analyzed. SOX17 and TRPS1 expression was assessed by immunohistochemistry and compared with established markers, including PAX8, GATA3, WT1, and calretinin. Sensitivity, specificity, and positive predictive value (PPV) were calculated according to the primary diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the tissue cohort, SOX17 showed 87% sensitivity and 100% specificity for M\u00fcllerian tumors, with no expression in breast carcinomas or mesothelial lesions, including tumors with PAX8\/WT1 co-expression. This specificity was retained in cell blocks, yielding a PPV of 100%. TRPS1 showed 98% sensitivity for breast carcinoma and identified 84% of GATA3-negative breast carcinomas. However, TRPS1 expression was also observed in 48% of tubo-ovarian serous carcinomas, limiting its PPV for breast carcinoma in effusions to 55% despite a negative predictive value of 97%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SOX17 is a highly specific confirmatory marker for M\u00fcllerian origin and may help resolve diagnostic pitfalls related to PAX8-positive mesothelial lesions. TRPS1 is a complementary marker for breast carcinoma, including GATA3-negative tumors, but its stand-alone diagnostic value is limited by cross-reactivity in M\u00fcllerian serous carcinomas. These findings support a panel-based approach for accurate primary-site attribution in malignant serous effusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10668969261472121","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:46:39Z","timestamp":1789825599000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["SOX17 and TRPS1 in M\u00fcllerian, Breast, and Mesothelial Tumors: Tissue-Based Specificity Profiles and Diagnostic Pitfalls in Malignant Serous Effusions"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3688-2768","authenticated-orcid":false,"given":"Gizem","family":"Issin","sequence":"first","affiliation":[{"name":"Erzincan Binali Yildirim University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Demir","sequence":"additional","affiliation":[{"name":"Duzce University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7527-7450","authenticated-orcid":false,"given":"Esra","family":"Yayl\u0131","sequence":"additional","affiliation":[{"name":"University of Health Sciences, \u00dcmraniye Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diren Vuslat","family":"\u00c7a\u011fatay","sequence":"additional","affiliation":[{"name":"Erzincan Binali Yildirim University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130smail","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Sultan II Abdulhamid Han Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia Bur\u00e7in","family":"Girgin","sequence":"additional","affiliation":[{"name":"Inonu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Gams\u0131zkan","sequence":"additional","affiliation":[{"name":"Duzce University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Zemheri","sequence":"additional","affiliation":[{"name":"University of Health Sciences, \u00dcmraniye Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Aktu\u011f","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Department of Pathology, Eskisehir City Hospital, Eskisehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lyas","family":"Sayar","sequence":"additional","affiliation":[{"name":"Erzincan Binali Yildirim University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fba","family":"Ta\u015fk\u0131n T\u00fcrkmeno\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ankara Etlik City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"949","volume-title":"Koss\u2019 diagnostic cytology and its histopathologic bases","author":"Koss LG","year":"2006","unstructured":"Koss LG, Melamed MR. Effusions in the presence of cancer. In: Koss\u2019 diagnostic cytology and its histopathologic bases. 5th ed. Lippincott Williams & Wilkins; 2006:949-1022.","edition":"5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0025-z"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.06.33"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.25259\/CMAS_02_05_2021"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-024-03872-y"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2022.04.002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-00692-8"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2026"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2022.100038"},{"issue":"3","key":"e_1_3_2_11_2","first-page":"138","article-title":"Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection in breast cancer tissue","volume":"8","author":"Remmele W","year":"1987","unstructured":"Remmele W, Stegner HE. Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection in breast cancer tissue. Pathologe. 1987;8(3):138\u2010140.","journal-title":"Pathologe"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000883"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqae104"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-026-01746-2"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22708"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.25468"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181da7687"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.10.036"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000001076"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.15470"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2022.100001"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2022.04.006"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqac066"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22663"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22901"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2025.04.001"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002213"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2023.11.012"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261472121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969261472121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261472121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:20:19Z","timestamp":1790097619000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969261472121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,19]]},"references-count":27,"alternative-id":["10.1177\/10668969261472121"],"URL":"https:\/\/doi.org\/10.1177\/10668969261472121","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,19]]},"article-number":"10668969261472121"}}