{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:45:55Z","timestamp":1791834355302,"version":"4.3.4"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"abstract":"<jats:p>\n                    This report describes two unique gonadal serous carcinomas, one low-grade serous carcinoma (LGSC) of the ovary and one serous carcinoma of the scrotum each harboring novel\n                    <jats:italic toggle=\"yes\">PAK<\/jats:italic>\n                    gene fusions. The first patient with ovarian LGSC was identified to have a\n                    <jats:italic toggle=\"yes\">PTPRM::PAK1<\/jats:italic>\n                    fusion, identifying\n                    <jats:italic toggle=\"yes\">PTPRM<\/jats:italic>\n                    as a novel fusion partner for\n                    <jats:italic toggle=\"yes\">PAK1<\/jats:italic>\n                    . The second patient with high-grade papillary serous carcinoma of the scrotum contained a\n                    <jats:italic toggle=\"yes\">DLG1::PAK2<\/jats:italic>\n                    fusion. Neither fusion was detected by DNA next-generation sequencing (NGS), highlighting the importance of RNA-based methodologies in identifying gene fusions. Overexpression of\n                    <jats:italic toggle=\"yes\">PAK1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">PAK2<\/jats:italic>\n                    has been reported in ovarian malignancies, correlating with tumor progression and reduced patient survival, while the significance of the unique fusions reported here warrants further consideration in relation to tumorigenesis and clinical implications.\n                  <\/jats:p>","DOI":"10.1177\/10668969261482144","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:24:56Z","timestamp":1791548696000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of PAK Gene Fusions in an Ovarian and a Testicular Serous Carcinoma"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4092-0816","authenticated-orcid":false,"given":"Nikka","family":"Khorsandi","sequence":"first","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffry P","family":"Simko","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Patrick","family":"Devine","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5462-2337","authenticated-orcid":false,"given":"Cynthia","family":"Gasper","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-4172","authenticated-orcid":false,"given":"Deepika","family":"Sirohi","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12020458"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2022.102497"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2024-005305"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.05.010"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-4183"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2022-003677"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrpr.2016.11.003"},{"issue":"2","key":"e_1_3_2_9_2","first-page":"116","article-title":"A rare case of serous papillary ovarian epithelial type carcinoma in testis: a rare testicular neoplasm","volume":"13","author":"Abdollahi A","year":"2019","unstructured":"Abdollahi A, Ensani F, Ayati M, Jahanian S, Eftekhar Javadi A, Khorsand A. 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