{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:45:56Z","timestamp":1791834356166,"version":"4.3.4"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">TFEB<\/jats:italic>\n                    -amplified renal cell carcinoma (RCC) is a rare, molecularly defined RCC, characterized by amplification of the\n                    <jats:italic toggle=\"yes\">TFEB<\/jats:italic>\n                    gene on chromosome 6p21.1, with fewer than 100 tumors reported to date. Herein, we report a\n                    <jats:italic toggle=\"yes\">TFEB<\/jats:italic>\n                    -amplified RCC with focal rhabdoid features, hyaline globules, giant tumor cells, and osseous metaplasia. This tumor further expands the histological spectrum of\n                    <jats:italic toggle=\"yes\">TFEB<\/jats:italic>\n                    -amplified RCC. A 59-year-old man underwent radical nephrectomy for a 7.6-cm left renal mass. Histologically, the tumor demonstrated predominantly papillary architecture (90%) with focal solid areas (10%). Tumor cells showed voluminous eosinophilic cytoplasm and prominent nucleoli. Additional findings included multifocal rhabdoid features (10%), intracellular hyaline globules, giant tumor cells, occasionally with multinucleation, osseous metaplasia, psammomatous calcifications, and focal tumor necrosis (5%). The tumor was classified as World Health Organization (WHO)\/International Society of Urological Pathology (ISUP) grade 4 and staged as pT2aNx. Immunohistochemically, the tumor cells were positive for PAX8, AMACR, and HNF1\u03b2, with rare Melan-A expression, and negative for keratin 7, CA9, GATA3, p63, ALK, cathepsin K, HMB45, and TFE3. RCC not otherwise specified (NOS) was initially diagnosed, and molecular testing was subsequently performed to further assist in the diagnosis. Chromosomal microarray analysis demonstrated amplification of chromosome 6p21.1 involving\n                    <jats:italic toggle=\"yes\">TFEB<\/jats:italic>\n                    and other genes with a reported copy number of \u22657, which was confirmed by fluorescence in situ hybridization demonstrating\n                    <jats:italic toggle=\"yes\">TFEB<\/jats:italic>\n                    copy-number gain with up to 9\n                    <jats:italic toggle=\"yes\">TFEB<\/jats:italic>\n                    signals per nucleus. Based on the morphology, immunoprofile, and molecular findings, the tumor was classified as\n                    <jats:italic toggle=\"yes\">TFEB<\/jats:italic>\n                    -amplified RCC. The patient subsequently developed widespread metastatic disease and received radiotherapy and systemic treatment. He remains alive with progression of disease at 45 months of follow-up.\n                  <\/jats:p>","DOI":"10.1177\/10668969261489621","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:30:38Z","timestamp":1791549038000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>TFEB<\/i>\n                    -Amplified Renal Cell Carcinoma With Focal Rhabdoid Features, Hyaline Globules, Giant Tumor Cells, and Osseous Metaplasia"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6538-7918","authenticated-orcid":false,"given":"Linjie","family":"Xiong","sequence":"first","affiliation":[{"name":"Mass General Brigham and Harvard Medical School, Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0768-4764","authenticated-orcid":false,"given":"Ting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Mass General Brigham and Harvard Medical School, Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Lee","family":"Wu","sequence":"additional","affiliation":[{"name":"Mass General Brigham and Harvard Medical School, Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.24"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14683"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000519"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000720"},{"issue":"7","key":"e_1_3_2_6_2","first-page":"651","article-title":"Clear cell renal cell carcinoma with osseous metaplasia: two extremely rare cases and review of the literature","volume":"73","author":"Cakici MC","year":"2020","unstructured":"Cakici MC, Kir G, Akalin MK, Yildirim A. Clear cell renal cell carcinoma with osseous metaplasia: two extremely rare cases and review of the literature. Arch Esp Urol. 2020;73(7):651-654. Carcinoma de celulas renales de celulas claras con metaplasia osea: dos casos extremadamente raros y revision de la literatura.","journal-title":"Arch Esp Urol"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2007.06.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2018.31.26.16137"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2014.10.002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001307"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002458"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092616"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.labinv.2025.105054"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13277"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.14681"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.5114\/pjp.2021.111769"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00779-w"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-022-03380-x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001408"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-00713-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.99"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318299f0fb"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000251"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200010000-00002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17172744"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002233"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002411"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqac126.164"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21068-9"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-023-01161-5"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.07.026"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2021.101767"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000002479"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2022.102041"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182613d8f"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.10.024"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.15761\/ICST.1000259"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2024.02.006"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2000.20376"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0046-8177(97)90026-5"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2005.01805.x"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1309\/F4TU-6AFE-R7NU-39Y3"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.32074\/1591-951X-28-19"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261489621","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10668969261489621","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10668969261489621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:59:16Z","timestamp":1791831556000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10668969261489621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":42,"alternative-id":["10.1177\/10668969261489621"],"URL":"https:\/\/doi.org\/10.1177\/10668969261489621","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]},"article-number":"10668969261489621"}}