{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:50:55Z","timestamp":1791568255384,"version":"4.3.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005026","name":"Stichting Tegen Kanker","doi-asserted-by":"publisher","award":["2025-048"],"award-info":[{"award-number":["2025-048"]}],"id":[{"id":"10.13039\/501100005026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"abstract":"<jats:p>\n                    Phyllodes tumors (PTs) are rare fibroepithelial neoplasms of the breast. PTs may pose significant diagnostic challenges, especially when they lack the classic leaf-like architecture and resemble cellular fibroadenomas. Accurate distinction between these entities is clinically important because of differences in management and recurrence risk. We report a 21-year-old woman who developed an early local recurrence of a fibroepithelial lesion initially diagnosed as a cellular complex fibroadenoma. The recurrence demonstrated stromal hypercellularity, multifocal infiltrative growth, and non-atypical smooth muscle differentiation without characteristic leaflike architecture, rendering morphological classification inconclusive. Next-generation sequencing demonstrated a pathogenic frameshift mutation in the\n                    <jats:italic toggle=\"yes\">BCOR<\/jats:italic>\n                    gene. When integrated with the patient's clinical history and the lesion's morphology, these molecular findings supported a diagnosis of borderline PT. This report emphasizes the importance of integrating histopathological, clinical, and molecular data in the evaluation of fibroepithelial lesions with ambiguous morphology. Molecular alterations, such as\n                    <jats:italic toggle=\"yes\">BCOR<\/jats:italic>\n                    mutations, may provide valuable diagnostic support, in particular in fibroadenoma-like PTs.\n                  <\/jats:p>","DOI":"10.1177\/10668969261489624","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:03:57Z","timestamp":1791392637000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Pathogenic\n                    <i>BCOR<\/i>\n                    Mutation Favors the Diagnosis of Borderline Phyllodes Tumor in a Fibroepithelial Lesion With Inconclusive Morphology and Early Recurrence"],"prefix":"10.1177","author":[{"given":"Pablo","family":"Garc\u00eda Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Isala Breast Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela M.","family":"Roman","sequence":"additional","affiliation":[{"name":"Isala Breast Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"De Vietro","sequence":"additional","affiliation":[{"name":"CHU Saint-Pierre \u2013 Site Alexiens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Gonzalez Antelo","sequence":"additional","affiliation":[{"name":"Cliniques universitaires Saint-Luc Bruxelles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Galant","sequence":"additional","affiliation":[{"name":"Cliniques universitaires Saint-Luc Bruxelles"},{"name":"UCLouvain, IREC, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-928X","authenticated-orcid":false,"given":"Mieke R.","family":"Van Bockstal","sequence":"additional","affiliation":[{"name":"Cliniques universitaires Saint-Luc Bruxelles"},{"name":"UCLouvain, IREC, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0583-3"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00430543"},{"key":"e_1_3_4_4_2","volume-title":"Breast Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2019","unstructured":"WHO Classification of Tumours Editorial Board. Breast Tumours. 5th ed. International Agency for Research on Cancer \/ World Health Organization; 2019.","edition":"5"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155389"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2025.105863"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/S00428-021-03175-6"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.15455"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2025.4392"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.157"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.4174\/ASTR.2023.105.6.353,"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1245\/S10434-024-15892-8,"},{"key":"e_1_3_4_13_2","unstructured":"National Comprehensive Cancer Network. NCCN guidelines breast cancer version 04.2025. https:\/\/www.nccn.org\/guidelines\/guidelines-detail?id=1419. 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