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Bony fragmentation, fracture, and dislocation progress to foot deformity, bony prominence, and instability. This often causes ulceration and deep infection that may necessitate amputation. Instability or deformity may limit the ability to use standard footwear. Treatment is focused on providing a stable and plantigrade foot for functional ambulation with accommodative footwear and orthoses. Historically, treatment had included nonweightbearing immobilization for the acute phase, and surgery had been reserved only for infection, unresolved skin ulceration, or deformity that precluded the use of therapeutic footwear. Current controversies include weightbearing in the acute or reparative phases and early surgical stabilization. Foot-specific patient education and continued periodic monitoring may reduce the morbidity and associated expense of treating the complications of this disorder and may improve the quality of life in this complex patient population.<\/jats:p>","DOI":"10.1177\/107110070502600109","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T10:07:23Z","timestamp":1486634843000},"page":"46-63","source":"Crossref","is-referenced-by-count":191,"title":["<i>Current Topics Review:<\/i>\n                    Charcot Neuroarthropathy of the Foot and Ankle"],"prefix":"10.1177","volume":"26","author":[{"given":"Elly","family":"Trepman","sequence":"first","affiliation":[{"name":"Winnipeg, Manitoba, Canada; Hull, East Yorkshire, UK; Maywood, IL"},{"name":"Presented in part at the 30th Annual Meeting of the American Orthopaedic Foot and Ankle Society, Specialty Day, Orlando, FL, March 18, 2000."},{"name":"Associate Professor, Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada; Assistant Editor, Foot & Ankle International; Co-founder, Canadian Orthopaedic Foot and Ankle Society"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneel","family":"Nihal","sequence":"additional","affiliation":[{"name":"Winnipeg, Manitoba, Canada; Hull, East Yorkshire, UK; Maywood, IL"},{"name":"Presented in part at the 30th Annual Meeting of the American Orthopaedic Foot and Ankle Society, Specialty Day, Orlando, FL, March 18, 2000."},{"name":"ConsultantOrthopaedicSurgeon, Hull Royal Infirmary, Hull, East Yorkshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Pinzur","sequence":"additional","affiliation":[{"name":"Winnipeg, Manitoba, Canada; Hull, East Yorkshire, UK; Maywood, IL"},{"name":"Presented in part at the 30th Annual Meeting of the American Orthopaedic Foot and Ankle Society, Specialty Day, Orlando, FL, March 18, 2000."},{"name":"Professor, Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, IL; Associate Editor, Foot & Ankle International; Board Member-at-Large, American Orthopaedic Foot and Ankle Society"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,1,1]]},"reference":[{"key":"bibr1-107110070502600109","doi-asserted-by":"publisher","DOI":"10.1177\/107110079401500702"},{"key":"bibr2-107110070502600109","doi-asserted-by":"publisher","DOI":"10.1007\/BF00276968"},{"key":"bibr3-107110070502600109","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199803000-00009"},{"key":"bibr4-107110070502600109","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/77.2.169"},{"key":"bibr5-107110070502600109","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199705)14:5<357::AID-DIA341>3.0.CO;2-8"},{"key":"bibr6-107110070502600109","doi-asserted-by":"publisher","DOI":"10.1177\/107110079701800106"},{"key":"bibr7-107110070502600109","doi-asserted-by":"publisher","DOI":"10.1177\/107110079801900912"},{"key":"bibr8-107110070502600109","doi-asserted-by":"publisher","DOI":"10.1007\/BF00197927"},{"key":"bibr9-107110070502600109","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-77-2-63"},{"key":"bibr10-107110070502600109","first-page":"14","volume":"296","author":"Bono JV","year":"1993","journal-title":"Clin. 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