{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:00:52Z","timestamp":1783609252926,"version":"3.55.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foot Ankle Int."],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p> Background: Displaced intraarticular calcaneal fractures may have a central cancellous bone defect area. We hypothesized that human demineralized bone matrix (DBM) calcium sulfate (CaSO<jats:sub>4<\/jats:sub>) might act as a reasonable alternative to autograft in calcaneal fractures. When combined with antibiotic powder, this bone graft substitute also may act as a local antibiotic delivery device. This is the first clinical study evaluating bone healing and complications associated with DBM-calcium sulfate bone graft substitute in the treatment of displaced intraarticular calcaneal fractures with a central cancellous bone defect. Methods: Over a 29-month period, 33 displaced intraarticular calcaneal fractures with central cancellous defects were treated with open reduction and internal fixation (ORIF) and grafting with vancomycin\/DBM-calcium sulfate bone graft substitute. Eleven fractures without bone defects were treated with ORIF only. Patient demographics, medical history, and CT fracture classification were recorded. Postoperatively, fractures were monitored every 2 weeks for healing and complications. Results: The mean time to union was 8.2 weeks in the grafted, while the control group mean time to union was 10.4 weeks ( p = 0.0117). Wound problems occurred in five (15%) of the 33 patients with grafting, all in type III fractures with severe soft-tissue swelling, and included two minor wound healing delays, and three serious wound problems. At a mean followup time of 22.4 months, no DBM-calcium sulfate grafted calcaneus demonstrated evidence of osteomyelitis. Conclusions: This is the first study examining human DBM-calcium sulfate bone graft substitute to treat displaced intraarticular calcaneal fractures. Based on these initial data, human DBM-calcium sulfate acted as an acceptable and safe autograft alternative in displaced intraarticular calcaneal fractures with moderate (5 cc to 10 cc) central cancellous bone defects. <\/jats:p>","DOI":"10.1177\/107110070602700702","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T11:11:16Z","timestamp":1484305876000},"page":"487-493","source":"Crossref","is-referenced-by-count":66,"title":["The Effect of Demineralized Bone Matrix-Calcium Sulfate with Vancomycin on Calcaneal Fracture Healing and Infection Rates: A Prospective Study"],"prefix":"10.1177","volume":"27","author":[{"given":"Christopher","family":"Bibbo","sequence":"first","affiliation":[{"name":"Director, Foot and Ankle Service, Department of Orthopaedics, Marshfield Clinic, Marshfield, WI"},{"name":"Clinical Instructor, Department of Orthopaedics and Rehabilitation, University of Wisconsin Medical School, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipak V.","family":"Patel","sequence":"additional","affiliation":[{"name":"Chief, Department of Orthopaedic Surgery, Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey"},{"name":"Clinical Instructor, Department of Orthopaedics and Rehabilitation, University of Wisconsin Medical School, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,7,1]]},"reference":[{"key":"bibr1-107110070602700702","doi-asserted-by":"publisher","DOI":"10.1177\/107110079801901211"},{"key":"bibr2-107110070602700702","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1383(00)00026-7"},{"key":"bibr3-107110070602700702","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199307000-00015"},{"key":"bibr4-107110070602700702","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/00003086-199305000-00008","volume":"290","author":"Bezes H","year":"1993","journal-title":"Clin. 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