{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:35:52Z","timestamp":1792607752882,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,2,5]],"date-time":"2013-02-05T00:00:00Z","timestamp":1360022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Foot Ankle Int."],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Fibromatous nodules in the sole of the foot are often called Ledderhose disease. It is a benign nodular formation in the plantar aponeurosis, typically at the distal medial border. A lump forms and it can be a few centimeters in diameter. It is frequently seen as an isolated disease, but a relationship to Dupuytren\u2019s has been noted in some patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study was a part of a large cohort study, the Reykjav\u00edk study. Men with Dupuytren\u2019s disease (n = 122) were invited to follow-up 18 years after the initial observation. An equal number of controls, matched for age and smoking habits, were also invited. A total of 92 Dupuytren\u2019s patients and 101 control subjects attended for follow-up and were examined for plantar nodules. Statistical evaluation was carried out using chi-square test and presented as odds ratio (OR) and 95% confidence interval (95% CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Ledderhose disease was identified in 14 of the 92 (15.2%) men with Dupuytren\u2019s disease, while it was only in 4 of the 101 (3.9%) matched controls (OR = 4.35, 95% CI, 1.3-16.7, P &lt; 0.01). Men operated for Dupuytren\u2019s disease or with finger contractures were more likely to have plantar nodules than those with only nodules or strings in the palms (OR = 6.1, 95% CI, 1.8-27.1, P &lt; 0.001). The plantar involvement was related to family history of Dupuytren\u2019s disease (OR = 3.1, 95% CI, 1.1-8.5, P = 0.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Men with manifestations of finger contractures or who need surgery for Dupuytren\u2019s disease are more likely to also develop plantar fibromas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>Level III, retrospective comparative series.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1071100713475352","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T02:18:46Z","timestamp":1360117126000},"page":"841-845","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Association of Morbus Ledderhose With Dupuytren\u2019s Contracture"],"prefix":"10.1177","volume":"34","author":[{"given":"Kristj\u00e1n G.","family":"Gudmundsson","sequence":"first","affiliation":[{"name":"Reykjavik Primary Health Care, Glaesibaer, Reykjavik, Iceland"},{"name":"University of Iceland, Reykjav\u00edk, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorbj\u00f6rn","family":"J\u00f3nsson","sequence":"additional","affiliation":[{"name":"University of Iceland, Reykjav\u00edk, Iceland"},{"name":"The Blood Bank, Landspitali University Hospital, Reykjav\u00edk, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reynir","family":"Arngr\u00edmsson","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Medicine, Landspitali University Hospital"},{"name":"Department of Biochemistry and Molecular Biology, BioMedical Center, University of Iceland, 101 Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,2,5]]},"reference":[{"key":"bibr1-1071100713475352","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-195537010-00002"},{"key":"bibr2-1071100713475352","first-page":"117","volume":"69","author":"Aviles E","year":"1971","journal-title":"Surgery"},{"key":"bibr3-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1007\/s001130050732"},{"key":"bibr4-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(91)90049-T"},{"key":"bibr5-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930290410"},{"key":"bibr6-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199205000-00013"},{"key":"bibr7-1071100713475352","first-page":"316","volume":"76","author":"Degreef I","year":"2010","journal-title":"Acta Orthop Belg"},{"key":"bibr8-1071100713475352","first-page":"456","volume":"74","author":"Degreef I","year":"2008","journal-title":"Acta Orthop Belg"},{"key":"bibr9-1071100713475352","volume-title":"Lecons oralis de Clinique chirurgicale faitesa l\u2019Hotel Dieu de Paris","author":"Dupuytren G","year":"1839"},{"key":"bibr10-1071100713475352","first-page":"129","volume":"18","author":"Farsetti P","year":"1992","journal-title":"Ital J Orthop Traumatol"},{"key":"bibr11-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1226(64)80066-7"},{"key":"bibr12-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1080\/030097401750065292"},{"key":"bibr13-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00145-6"},{"key":"bibr14-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198902000-00016"},{"key":"bibr15-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-009-2049-x"},{"key":"bibr16-1071100713475352","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1960.tb24004.x"},{"key":"bibr17-1071100713475352","volume-title":"Dupuytren\u2019s Disease","author":"Hueston JT","year":"1978","edition":"2"},{"key":"bibr18-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(05)80273-6"},{"key":"bibr19-1071100713475352","first-page":"694","volume":"55","author":"Ledderhose G","year":"1897","journal-title":"Arch Klin Chir"},{"key":"bibr20-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2012.01.004"},{"key":"bibr21-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195107)4:4<846::AID-CNCR2820040422>3.0.CO;2-N"},{"key":"bibr22-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1177\/107110070002100706"},{"key":"bibr23-1071100713475352","first-page":"1","volume":"139","author":"Skoog T","year":"1948","journal-title":"Acta Chir Scand"},{"key":"bibr24-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31817d61ab"},{"key":"bibr25-1071100713475352","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1981.01650060065031"}],"container-title":["Foot &amp; 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