{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:12:30Z","timestamp":1779185550208,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Foot Ankle Int."],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Negative Pressure Wound Therapy (NPWT) is frequently utilized to manage complex wounds, however its mechanisms of healing remain poorly understood. Changes in growth factor expression, micro- and macro-deformation, blood flow, exudate removal, and bacterial concentration within the wound bed are thought to play a role. NPWT is gaining widespread usage in foot and ankle surgery, including the management of traumatic wounds; diabetic and neuropathic ulcers; wounds left open after debridement for infection or dehiscence; high-risk, closed incisions; tissue grafts and free flaps. This article reviews the rationale for NPWT, its proposed mechanisms of action, and the evidence regarding its clinical applications within the field of foot and ankle surgery.<\/jats:p>\n                  <jats:p>Level of Evidence: Level V, expert opinion.<\/jats:p>","DOI":"10.1177\/1071100719892962","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T07:31:37Z","timestamp":1576222297000},"page":"364-372","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Negative-Pressure Wound Therapy in Foot and Ankle Surgery"],"prefix":"10.1177","volume":"41","author":[{"given":"Kyle N.","family":"Kunze","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran S.","family":"Hamid","sequence":"additional","affiliation":[{"name":"Department of 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