{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:10:00Z","timestamp":1777612200429,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Foot Ankle Int."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aimed to mimic the changes from Charcot neuropathic arthropathy in humans by examining the effects of exposing diet-induced obese (DIO) mice to neurotrauma through a regimented running protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty-eight male wild-type C57BL\/6J mice were obtained at age 6\u2009weeks and separated into 2 groups for diet assignment. After a 1-week acclimation period, half of the mice consumed a high-fat diet (60% fat by kcal) ad libitum to facilitate neuropathic diet-induced obesity whereas the other half were control mice and consumed an age-matched standard low-fat control diet (10% fat by kcal). At age 12\u2009weeks, half of the animals from each group were subjected to a high-intensity inclined treadmill running protocol, which has been previously demonstrated to induce neurotrauma. Sensory testing and radiographic analyses were periodically performed. Histopathologic analyses were performed post killing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>DIO mice had significantly higher bodyweights, higher body fat percentages, and lower bone mineral density than wildtype control mice that were fed a normal diet throughout the experiment ( P\u2009&lt;\u2009.001 for each). DIO mice displayed significantly reduced sensory function in week 1 ( P\u2009=\u2009.005) and this worsened over time, requiring 20.6% more force for paw withdrawal by week 10 ( P\u2009&lt;\u2009.001). DIO mice that ran demonstrated greater midfoot subluxation and tarsal instability over all time points compared with normal-diet mice that ran ( P\u2009&lt;\u2009.001). Histopathologic analyses revealed that DIO mice that ran demonstrated significant changes compared with controls that ran ( P\u2009&lt;\u2009.001 for each parameter).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Changes akin to the earliest changes observed in or before joint destruction identified in diabetic Charcot neuropathic arthropathy in humans were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance:<\/jats:title>\n                    <jats:p>There is currently no standard of treatment for patients with Charcot neuropathic arthropathy. This study establishes a protocol for an animal model that can be used to study and compare interventions to treat this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10711007231198822","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T08:30:36Z","timestamp":1697013036000},"page":"1278-1286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Establishment of a Neurodegenerative Charcot Mouse Model"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7645-8179","authenticated-orcid":false,"given":"Zachary A.","family":"Koroneos","sequence":"first","affiliation":[{"name":"Center for Orthopaedic Research and Translational Science, The Pennsylvania State University, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ptasinski","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine, The Pennsylvania State University, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9484-599X","authenticated-orcid":false,"given":"Christopher","family":"Stauch","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine, The Pennsylvania State University, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonya S.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Division of Biostatistics and Bioinformatics, The Pennsylvania State University, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie C.","family":"Fanburg-Smith","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Orthopaedics, Pediatrics, Center for Orthopaedic Research and Translational Science, Penn State College of Medicine, The Pennsylvania State University, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-4927","authenticated-orcid":false,"given":"Michael","family":"Aynardi","sequence":"additional","affiliation":[{"name":"Center for Orthopaedic Research and Translational Science, The Pennsylvania State University, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"bibr1-10711007231198822","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-92-7-390"},{"key":"bibr2-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAMCOLLSURG.2011.05.019"},{"key":"bibr3-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1111\/JNS5.12072"},{"key":"bibr4-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.113154"},{"key":"bibr5-10711007231198822","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S64625"},{"key":"bibr6-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-6-30"},{"key":"bibr7-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0B013E3181C6F55B"},{"key":"bibr8-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1177\/1071100716646629"},{"key":"bibr9-10711007231198822","volume-title":"Mann\u2019s Surgery of the Foot and Ankle, 2-Volume Set","author":"Coughlin MJ","year":"2014","edition":"9"},{"key":"bibr10-10711007231198822","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2017.01378\/BIBTEX"},{"key":"bibr11-10711007231198822","doi-asserted-by":"publisher","DOI":"10.3389\/FNMOL.2017.00284"},{"key":"bibr12-10711007231198822","doi-asserted-by":"publisher","DOI":"10.3791\/54052"},{"key":"bibr13-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1007\/BF00253862"},{"key":"bibr14-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1016\/J.FOOT.2018.02.001"},{"issue":"3","key":"bibr15-10711007231198822","first-page":"372","volume":"20","author":"Gkastaris K","year":"2020","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"bibr16-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1002\/JOR.20546"},{"key":"bibr17-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1111\/J.1529-8027.2012.00390.X"},{"key":"bibr18-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199707)14:7<527::AID-DIA404>3.0.CO;2-Q"},{"key":"bibr19-10711007231198822","first-page":"169","volume":"51","author":"Guyton GP","year":"2002","journal-title":"Instr Course Lect"},{"key":"bibr20-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/149452"},{"key":"bibr21-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1016\/J.JDIACOMP.2018.09.013"},{"key":"bibr22-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1002\/CPMO.11"},{"key":"bibr23-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1016\/J.ANNDIAGPATH.2020.151509"},{"key":"bibr24-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1016\/J.JDIACOMP.2012.04.008"},{"key":"bibr25-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.2003.18.11.2002"},{"key":"bibr26-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1093\/ILAR\/ILT052"},{"key":"bibr27-10711007231198822","doi-asserted-by":"publisher","DOI":"10.2337\/DB06-1176"},{"key":"bibr28-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1186\/S12944-018-0852-Z\/FIGURES\/4"},{"key":"bibr29-10711007231198822","doi-asserted-by":"publisher","DOI":"10.3402\/DFA.V4I0.20872"},{"key":"bibr30-10711007231198822","doi-asserted-by":"publisher","DOI":"10.2337\/DC10-0636"},{"key":"bibr31-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1111\/J.1464-5491.2005.01510.X"},{"key":"bibr32-10711007231198822","doi-asserted-by":"publisher","DOI":"10.4172\/2161-0460.1000403"},{"key":"bibr33-10711007231198822","doi-asserted-by":"publisher","DOI":"10.2337\/DC08-1695"},{"key":"bibr34-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1016\/J.ANNDIAGPATH.2021.151878"},{"key":"bibr35-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1177\/1071100716674434"},{"key":"bibr36-10711007231198822","doi-asserted-by":"publisher","DOI":"10.2337\/DB09-0047"},{"key":"bibr37-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-430-8_27"},{"key":"bibr38-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1177\/1071100714547218"},{"key":"bibr39-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/305205"},{"key":"bibr40-10711007231198822","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1804869"}],"container-title":["Foot &amp; Ankle International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10711007231198822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10711007231198822","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10711007231198822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:22:00Z","timestamp":1777411320000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10711007231198822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,11]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1177\/10711007231198822"],"URL":"https:\/\/doi.org\/10.1177\/10711007231198822","relation":{},"ISSN":["1071-1007","1944-7876"],"issn-type":[{"value":"1071-1007","type":"print"},{"value":"1944-7876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,11]]}}}