{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:49:58Z","timestamp":1780541398259,"version":"3.54.1"},"reference-count":18,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Foot Ankle Int."],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The Infectious Diseases Society of America guidelines recommend a prolonged course of antibiotics in the setting of residual osteomyelitis. More recently published literature suggests that oral antibiotics may offer comparable outcomes to intravenously administered antibiotics when treating orthopaedic infections. In a prior study, we investigated the outcomes of both routes of antibiotic administration in patients with diabetic foot infections at a single academic medical institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The goal of this study is to retrospectively evaluate the therapeutic success in 196 patients receiving oral or intravenous antibiotics for treatment of residual infection following amputation at 2 academic medical centers. Treatment was considered successful if patients who completed a minimum of 4\u2009weeks of antibiotic therapy had complete wound healing and did not require additional debridement or amputation within 1 year of their initial surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      After performing a retrospective chart review, no difference was determined in treatment success between patients who underwent oral or intravenous antibiotics at either WFBMC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.34) or UPMC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.99). No difference in success was found when combining institutional data (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.52). The median time to healing for oral antibiotics was 3.21\u2009months compared with 3.85\u2009months for intravenous (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.16). Reoperation rates did not differ among treatment types (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.53). Hemoglobin A\n                      <jats:sub>1c<\/jats:sub>\n                      values were lower among patients with treatment success (8.6\u2009\u00b1\u20092.3) versus failure (9.5\u2009\u00b1\u20092.5) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study supports the consideration of oral antibiotics as a viable option for selected diabetic patients with residual osteomyelitis. No significant differences were observed in treatment success, healing time, or reoperation rates, although the study was not powered to determine equivalence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10711007251344583","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T04:26:51Z","timestamp":1757392011000},"page":"1083-1089","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A Retrospective Cohort Study From 2 Academic Medical Centers: Oral vs Intravenous Antibiotics for Diabetic Osteomyelitis"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5790-9977","authenticated-orcid":false,"given":"Jennifer A.","family":"Kipp","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery and Rehabilitation, Atrium Health Wake Forest Baptist Medical Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay K.","family":"LeSavage","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Rehabilitation, Atrium Health Wake Forest Baptist Medical Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5794-4326","authenticated-orcid":false,"given":"Joni K.","family":"Evans","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C.","family":"Tolin","sequence":"additional","affiliation":[{"name":"UPMC Mercy Hospital, Podiatric Medicine and Surgery Resident, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianne","family":"Vesce","sequence":"additional","affiliation":[{"name":"UPMC Mercy Hospital, Podiatric Medicine and Surgery Resident, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Denmeade","sequence":"additional","affiliation":[{"name":"Section on Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Charlotte, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Arbulu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, UPMC Mercy Hospital, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Manway","sequence":"additional","affiliation":[{"name":"Foot and Ankle Division, UPP Department of Orthopaedic Surgery, UPMC Mercy Hospital, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody D.","family":"Blazek","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Rehabilitation and Department of Vascular and Endovascular Surgery, Atrium Health Wake Forest Baptist Medical Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2012.06.017"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2021.09.029"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.176"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2021.107960"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.01.011"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2021.11.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2024.03.003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2010.12.009"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199805000-00021"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710926"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis460"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac450"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15314.4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201904_17471"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2012.02.004"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.7547\/14-036.1"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3687"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fcl.2022.02.004"}],"container-title":["Foot &amp; 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