{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:09:58Z","timestamp":1787497798325,"version":"build-2736575974"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Foot Ankle Int."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study evaluated the relationship between antidepressant prescription (ADP) and postoperative complications in patients undergoing ankle open reduction internal fixation (ORIF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A retrospective cohort study that uses multi-institutional data from the Trinetx research platform identified patients who underwent ankle ORIF on or before December 10, 2024, with at least 2 ADP doses and 2 years of follow-up using\n                      <jats:italic toggle=\"yes\">Current Procedural Terminology<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">CPT<\/jats:italic>\n                      ) and\n                      <jats:italic toggle=\"yes\">International Classification of Diseases, Tenth Revision<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">ICD-10<\/jats:italic>\n                      ) codes. Outcomes were grouped into 90-day systemic and 2-year mechanical complication families. The false discovery rate was controlled at 5% using the Benjamini-Hochberg procedure, and results are reported as risk ratios with 95% CIs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 70\u2009813 patients, 13\u2009610 (19.2%) used antidepressants. After matching (11.071 per group), antidepressant use was associated with significantly higher rates of short-term complications, including infection, wound disruption, and hospital readmission. At 2-year follow-up, use of antidepressants was significantly associated with increased rates of mechanical complications, including higher rates of hardware failure, osteoarthritis, removal, nonunion, and amputation. The outcomes remained significant after multiple-testing adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Preoperative antidepressant prescription was associated with increased postoperative and long-term complications after ankle ORIF. These observational findings support tailored perioperative management and monitoring, particularly for patients with preoperative antidepressant prescriptions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10711007251401513","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T05:41:39Z","timestamp":1769233299000},"page":"398-413","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Antidepressant Use on Complications Following Ankle Fracture Management: A Multi-institutional Propensity-Matched Cohort Analysis"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5184-9648","authenticated-orcid":false,"given":"Amir","family":"Alsaidi","sequence":"first","affiliation":[{"name":"Paul L. 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